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首页> 外文期刊>Journal of Surgical Oncology >Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer.
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Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer.

机译：诱导型一氧化氮合酶和环氧合酶-2在人胃癌血管生成和临床结局中的表达。

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BACKGROUND AND OBJECTIVES: It has been recognized that inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) produce important endogenous factors of human tumors such as nitric oxide (NO) and prostaglandins, which is involved in the process of carcinogenesis and tumor progression. This study aimed to evaluate the association of clinicopathologic factors, microvessel density, and patient survival with the expression of iNOS and COX-2 in patients with gastric adenocarcinoma. MATERIALS AND METHODS: Seventy-nine specimens, resected from patients with gastric adenocarcinoma, were investigated by immunohistochemical stain against iNOS and COX-2. Microvessels were stained using anti-CD34 antibody and counted as microvessel density. RESULTS: Positive iNOS and COX-2 expressions were significantly correlated with microvessel density by multivariate analysis, respectively (P = 0.0127 vs. P = 0.0214). There was significant difference among the four groups (both iNOS and COX-2 positive, iNOS positive only, COX-2 positive only, and both negative) in serosal invasion (P = 0.038), lymph node metastasis (P = 0.038), Helicobacter pylori infection (P = 0.025), vascular invasion (P = 0.035), and microvessel density (P = 0.019). In patients with gastric cancer that co-expressed iNOS and COX-2, prognosis was significantly poorer than in those that expressed either iNOS or COX-2, or did not express both of them (P = 0.01738). The Cox proportional hazard regression analysis indicated that iNOS expression, vascular invasion, serosal invasion, and microvessel density are independent prognostic factors for patients with gastric cancer. CONCLUSIONS: iNOS and COX-2 expression of gastric cancer are related to tumor angiogenesis, tumor progression, and patient survival in human gastric cancer.
机译：背景与目的：已经认识到诱导型一氧化氮合酶（iNOS）和环氧合酶（COX-2）会产生人类肿瘤的重要内源性因子，例如一氧化氮（NO）和前列腺素，它们参与了癌变和肿瘤的形成过程。进展。本研究旨在评估胃腺癌患者临床病理因素，微血管密度和患者生存率与iNOS和COX-2表达的关系。材料与方法：采用免疫组织化学方法对iNOS和COX-2进行免疫组化染色，从胃腺癌患者中切除了79例标本。使用抗CD34抗体对微血管染色，并计数为微血管密度。结果：通过多变量分析，iNOS和COX-2阳性表达分别与微血管密度显着相关（P = 0.0127 vs. P = 0.0214）。浆膜浸润（P = 0.038），淋巴结转移（P = 0.038），幽门螺杆菌这四组（iNOS和COX-2阳性，仅iNOS阳性，仅COX-2阳性，且两者均为阴性）之间存在显着差异。幽门螺杆菌感染（P = 0.025），血管侵犯（P = 0.035）和微血管密度（P = 0.019）。在胃癌中同时表达iNOS和COX-2的患者，其预后显着低于那些同时表达iNOS或COX-2或不表达两者的患者（P = 0.01738）。 Cox比例风险回归分析表明，iNOS表达，血管浸润，浆膜浸润和微血管密度是胃癌患者的独立预后因素。结论：胃癌中iNOS和COX-2的表达与人胃癌的肿瘤血管生成，肿瘤进展和患者生存率有关。

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