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首页> 外文期刊>World Journal of Gastroenterology >Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases
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Neuroendocrine markers in adenocarcinomas: an investigation of 356 cases

机译：腺癌中神经内分泌标志物的调查：356例

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AIM: To investigate the incidence of neuroendocrine (NE) cells and their hormone products in adenocarcinomas and evaluate their significance in clinical pathology and prognosis. METHODS: By using tissue sectioning and immunocyto-chemistry, 356 cases of adenocarcinomas were studied to examine the presence of chromorgranin and polypeptide hormones in adenocarcinoma samples from our hospital. RESULTS: The positive rate of NE cells and hormone products was 41.5 % (54/130) and 59.3 % (32/54), respectively in large intestinal adenocarcinoma cases; 39.6 % (38/96) and 36.8 % (14/38), respectively in gastric cancer cases; 38.1 % (8/21) and 50.0 % (4/8), respectively in prostatic cancer cases; 21.0 % (17/81) and 17.6 % (3/17), respectively in breasr cancer cases; 17.9 % (5/28) and 60.0 % (3/5), respectively in pancreatic cancer cases. Among carcinomas of large intestine, pancreas and breast, the highly differentiated NE cell numbers were higher than the poorly differentiated NE cell numbers; while the gastric carcinoma cases had more poorly differentiated NE cells than highly differentiated NE cells. The higher detection rate of NE cells and their hormone products, the higher 5-year survival rate among the large intestine cancer cases. CONCLUSION: Close correlation was observed between NE cells and their hormone products with the cancer differentiations. For colorectal carcinomas, there is a close correlation of the presence of NE cells and their hormone products with the tumor staging and prognosis.
机译：目的：探讨腺癌中神经内分泌（NE）细胞及其激素产物的发生率，并评估其在临床病理和预后中的意义。方法：采用组织切片和免疫细胞化学方法，对356例腺癌进行研究，以检查我院腺癌样本中嗜铬粒蛋白和多肽激素的含量。结果：在大肠腺癌中，NE细胞和激素产物的阳性率分别为41.5％（54/130）和59.3％（32/54）。胃癌病例分别为39.6％（38/96）和36.8％（14/38）；前列腺癌病例分别为38.1％（8/21）和50.0％（4/8）；在breasr癌病例中，分别为21.0％（17/81）和17.6％（3/17）；胰腺癌病例分别为17.9％（5/28）和60.0％（3/5）。在大肠癌，胰腺癌和乳腺癌中，高分化的NE细胞数量高于低分化的NE细胞数量。而胃癌病例中分化程度较弱的NE细胞要多。在大肠癌病例中，NE细胞及其激素产物的检出率越高，5年生存率越高。结论：NE细胞及其激素产物与癌症分化密切相关。对于大肠癌，NE细胞及其激素产物的存在与肿瘤分期和预后密切相关。

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