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首页> 外文期刊>World Journal of Gastroenterology >Ultrastructure and molecular biological changes of chronic gastritis, gastric cancer and gastric precancerous lesions: a comparative study
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Ultrastructure and molecular biological changes of chronic gastritis, gastric cancer and gastric precancerous lesions: a comparative study

机译：慢性胃炎，胃癌和胃癌前病变的超微结构和分子生物学变化：比较研究

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AIM: To carry out a comparative study on ultrastructure and molecular biological changes of chronic gastritis (CG), gastric cancer (GC) aand gastric precancerous lesions. METHODS: By the use of histochemical staining, SEM with EDAX, TEM with EDAX, image analysis technique, RIA and chemiluminescence method, gastric mucosa of 168 patients were synchronously analyzed in morphology, trace elements, DNA, cAMP, SOD, ~3H-TdR LCT and serum LPO were also done. CONCLUSION: There was a significant difference between CG and GC in their ultrastructure and molecular biology. Only on the condition of changes of internal environment in combination with the harmful effect of external environment, chronic atrophic gastritis can then develop into gastric cancer. Hence it might have similar epithelial cell ultrastructure and molecular biological changes in ATP~(++), IMII_b and cancer, hence there were similar patterns of occurrence, development and transformation. Recognition of this trend might help to explore problems of prevention and cure.
机译：目的：比较慢性胃炎（CG），胃癌（GC）和胃癌前病变的超微结构和分子生物学变化。方法：利用组织化学染色，EDAX SEM，EDAX TEM，图像分析技术，RIA和化学发光法，对168例胃黏膜的形态，微量元素，DNA，cAMP，SOD，〜3H-TdR进行同步分析。还进行了LCT和血清LPO。结论：CG和GC在超微结构和分子生物学上存在显着差异。仅在内部环境变化并结合外部环境的有害影响的情况下，慢性萎缩性胃炎才可以发展为胃癌。因此，它可能在ATP〜（++），IMII_b和癌症中具有相似的上皮细胞超微结构和分子生物学变化，因此具有相似的发生，发展和转化模式。对这一趋势的认识可能有助于探索预防和治疗的问题。

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