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首页> 外文期刊>World Journal of Gastroenterology >Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance
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Expression of p27, cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance

机译：p27，cyclin E和cyclin A在肝细胞癌中的表达及其临床意义

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摘要

AIM: To investigate the expression of p27, cyclin E and cyclin A in hepatocellular carcinoma (HCC) and its potential clinical significance. METHODS: Expression of p27, cyclin E and cyclin A in 45 HCC specimens and 30 adjacent noncancerous lesions obtained from 45 patients during surgery was examined by immunohistochemical SABC assay. The diameter of tumor ranged from 1 cm to 19 cm (d≤5 cm, 9 samples; 5 cm10 cm, 17 samples). The tumors were graded according to the criteria described by Edmondson-Steiner: well-differentiated HCC group (Grade Ⅰ+Ⅱ), 26 samples; poorly-differentiated HCC group (Grade Ⅲ+Ⅳ), 19 samples. According to the clinical-pathologic features, 19 samples were poorly encapsulated, 15 samples had portal invasion of cancer, 11 samples had extrahepatic metastasis, and 12 samples had intrahepatic metastasis. All of the samples were classified as the invasive and metastatic group, while the remaining was classified as the non-invasive and non- metastatic group. RESULTS: The average labeling index (LI) of p27 in HCC lesions was significantly higher than that in adjacent noncancerous lesions (45.87+-14.21 vs33.77+-12.92, t=3.745, P<0.001). The LI of p27 was associated with differentiation, invasiveness and metastasis of the tumors (34.46+-12.29 vs 52.80+-11.36, t=5.17; 41.42+-12.86 vs 51.44+-14.10, t=2.48; P<0.05). Cyclin E was overexpressed in 16 cases (35.6%) while cyclin A was overexpressed in 21 cases (46.7%) in HCC lesions. No overexpression of cyclin E or cyclin A could be observed in adjacent non-carcinoma lesions and normal liver tissues. The overexpressions of cyclin E and cyclin A were correlated with differentiation, tumor thrombus, invasiveness and metastasis (P<0.05). Expression of cyclin E was significantly correlated with expression of cyclin A (r=0.329, P<0.05). The LI of p27 was significantly decreased in cyclin E, cyclin A positive groups (40.33+-11.91 vs 49.50+-13.76, t=3.05; 38.86+-11.19 vs 52.57+-12.62, t=3.89; P<0.05). CONCLUSION: p27, cyclin E, cyclin A play cooperative roles in HCC tumorigenesis, differentiation, invasiveness and metastasis. Detection of their expression may be helpful in prediction of tumor progression.
机译：目的：探讨p27，cyclin E和cyclin A在肝细胞癌（HCC）中的表达及其潜在的临床意义。方法：采用免疫组织化学SABC法检测45例肝癌标本和45例患者手术切除的30例癌旁非癌性病变中p27，cyclin E和cyclin A的表达。肿瘤的直径为1cm至19cm（d≤5cm，9个样品； 5cm ＜d≤10cm，19个样品； d＞ 10cm，17个样品）。肿瘤按Edmondson-Steiner描述的标准分级：高分化肝癌组（Ⅰ+Ⅱ级），26个样本； HCC低分化组（Ⅲ+Ⅳ级）19例。根据临床病理特征，包埋不良的标本19份，癌门脉浸润的标本15份，肝外转移的标本11份，肝内转移的标本12份。所有样品均被分类为浸润和转移组，其余样品被分类为非浸润和非转移组。结果：HCC病变中p27的平均标记指数（LI）显着高于相邻的非癌性病变（45.87 + -14.21 vs 33.77 + -12.92，t = 3.745，P <0.001）。 p27的LI与肿瘤的分化，侵袭性和转移相关（34.46 + -12.29 vs 52.80 + -11.36，t = 5.17; 41.42 + -12.86 vs 51.44 + -14.10，t = 2.48; P <0.05）。在肝癌病变中，Cyclin E高表达16例（35.6％），而cyclin A高表达21例（46.7％）。在邻近的非癌性病变和正常肝组织中未观察到细胞周期蛋白E或细胞周期蛋白A的过表达。细胞周期蛋白E和细胞周期蛋白A的高表达与分化，肿瘤血栓，浸润和转移相关（P <0.05）。细胞周期蛋白E的表达与细胞周期蛋白A的表达显着相关（r = 0.329，P <0.05）。在细胞周期蛋白E，细胞周期蛋白A阳性组中p27的LI显着降低（40.33 + -11.91 vs 49.50 + -13.76，t = 3.05; 38.86 + -11.19 vs 52.57 + -12.62，t = 3.89; P <0.05）。结论：p27，cyclin E，cyclin A在肝癌的发生，分化，侵袭和转移中起着协同作用。检测它们的表达可能有助于预测肿瘤的进展。

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  • 来源
    《World Journal of Gastroenterology》 |2003年第11期|p.2450-2454|共5页
  • 作者

    Qi Zhou; Qiang He; Li-Jian Liang;

  • 作者单位

    Department of Hepatobilliary Surgery, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guandong Province, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 消化系及腹部疾病;
  • 关键词

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