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Expression of p27 cyclin E and cyclin A in hepatocellular carcinoma and its clinical significance

机译：p27cyclin E和cyclin A在肝细胞癌中的表达及其临床意义

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AIM: To investigate the expression of p27, cyclin E and cyclin A in hepatocellular carcinoma (HCC) and its potential clinical significance.METHODS: Expression of p27, cyclin E and cyclin A in 45 HCC specimens and 30 adjacent noncancerous lesions obtained from 45 patients during surgery was examined by immunohistochemical SABC assay. The diameter of tumor ranged from 1 cm to 19 cm (d ≤ 5 cm, 9 samples; 5 cm < d ≤ 10 cm, 19 samples; d > 10 cm, 17 samples). The tumors were graded according to the criteria described by Edmondson-Steiner: well-differentiated HCC group (Grade I + II), 26 samples; poorly-differentiated HCC group (Grade III + IV), 19 samples. According to the clinical-pathologic features, 19 samples were poorly encapsulated, 15 samples had portal invasion of cancer, 11 samples had extrahepatic metastasis, and 12 samples had intrahepatic metastasis. All of the samples were classified as the invasive and metastatic group, while the remaining was classified as the non-invasive and non- metastatic group.RESULTS: The average labeling index (LI) of p27 in HCC lesions was significantly higher than that in adjacent noncancerous lesions (45.87 ± 14.21 vs 33.77 ± 12.92, t = 3.745, P < 0.001). The LI of p27 was associated with differentiation, invasiveness and metastasis of the tumors (34.46 ± 12.29 vs 52.80 ± 11.36, t = 5.17; 41.42 ± 12.86 vs 51.44 ± 14.10, t = 2.48; P < 0.05). Cyclin E was overexpressed in 16 cases (35.6%) while cyclin A was overexpressed in 21 cases (46.7%) in HCC lesions. No overexpression of cyclin E or cyclin A could be observed in adjacent non-carcinoma lesions and normal liver tissues. The overexpressions of cyclin E and cyclin A were correlated with differentiation, tumor thrombus, invasiveness and metastasis (P < 0.05). Expression of cyclin E was significantly correlated with expression of cyclin A (r = 0.329, P < 0.05). The LI of p27 was significantly decreased in cyclin E, cyclin A positive groups (40.33 ± 11.91 vs 49.50 ± 13.76, t = 3.05; 38.86 ± 11.19 vs 52.57 ± 12.62, t = 3.89; P < 0.05).CONCLUSION: p27, cyclin E, cyclin A play cooperative roles in HCC tumorigenesis, differentiation, invasiveness and metastasis. Detection of their expression may be helpful in prediction of tumor progression.
机译：目的：探讨p27，cyclin E和cyclin A在肝细胞癌（HCC）中的表达及其潜在的临床意义。方法：p45，cyclin E和cyclin A在45例HCC和45例患者的30例非癌性病变中的表达在手术期间通过免疫组织化学SABC测定法进行检查。肿瘤的直径为1 cm至19 cm（d≤5 cm，9个样本； 5 cm 10 cm，17个样本）。根据Edmondson-Steiner描述的标准对肿瘤进行分级：高分化肝癌组（I + II级），26个样本；低分化肝癌组（III + IV级），19个样本。根据临床病理特征，包埋不良的标本19份，癌门脉浸润的标本15份，肝外转移的标本11份，肝内转移的标本12份。结果：所有样本均被划为浸润转移组，其余均为非浸润转移组。结果：肝癌组织中p27的平均标记指数（LI）明显高于癌旁组织。非癌性病变（45.87±14.21 vs 33.77±12.92，t = 3.745，P <0.001）。 p27的LI与肿瘤的分化，侵袭性和转移相关（34.46±12.29 vs 52.80±11.36，t = 5.17; 41.42±12.86 vs 51.44±14.10，t = 2.48; P <0.05）。在肝癌病变中，Cyclin E高表达16例（35.6％），而cyclin A高表达21例（46.7％）。在邻近的非癌性病变和正常肝组织中未观察到细胞周期蛋白E或细胞周期蛋白A的过表达。细胞周期蛋白E和细胞周期蛋白A的过表达与分化，肿瘤血栓，浸润和转移相关（P <0.05）。细胞周期蛋白E的表达与细胞周期蛋白A的表达显着相关（r = 0.329，P <0.05）。结论：细胞周期蛋白p27在细胞周期蛋白E阳性细胞周期蛋白E阳性组中显着下降（40.33±11.91 vs 49.50±13.76，t = 3.05; 38.86±11.19 vs 52.57±12.62，t = 3.89; P <0.05）。 E，细胞周期蛋白A在肝癌的发生，分化，侵袭和转移中起着协同作用。检测它们的表达可能有助于预测肿瘤的进展。

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