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首页> 外文期刊>World Journal of Gastroenterology >Combined transarterial chemoembolization and arterial administration of Bletilla striata in treatment of liver tumor in rats
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Combined transarterial chemoembolization and arterial administration of Bletilla striata in treatment of liver tumor in rats

机译：白内障联合经动脉化学栓塞和动脉给药治疗大鼠肝肿瘤

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AIM: To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. METHODS: Subcapsular implantation of a solid Morris hepatoma 3 924A (2 mm~3) in the liver was carried out in 30 male ACI rats. Tumor volume (V1) was measured by magnetic resonance imaging (MRI) on day 13 after implantation. The following different agents of interventional treatment were injected after retrograde catheterization via gastroduodenal artery (on day 14), namely, (A) TACE (0.1 mg mitomycin + 0.1 ml Lipiodol) + Bletilla striata (1.0 mg) (n=10); (B) TACE + Bletilla striata (1.0 mg) + ligation of hepatic artery (n=10), (C) TACE alone (control group, n=10). Tumor volume (V2) was assessed by MRI (on day 13 after treatment) and the tumor growth ratio (V2/V1) was calculated. RESULTS: The mean tumor volume before (V1) and after (V2) treatment was 0.0355 cm~3 and 0.2248 cm~3 in group A, 0.0374 cm~3 and 0.0573 cm~3 in group B, 0.0380 cm~3 and 0.3674 cm~3 in group C, respectively. The mean ratio (V2/V1) was 6.2791 in group A, 1.5324 in group B and 9.1382 in group C. Compared with the control group (group C), group B showed significant inhibition of tumor growth (P<0.01), while group A did not (P>0.05). None of the animals died during implantation or in the postoperative period. CONCLUSION: Combination of TACE and arterial administration of Bletilla striata plus ligation of hepatic artery is more effective than TACE alone in the treatment of HCC in rats.
机译：目的：评估并比较经动脉化学栓塞（TACE）和白术（抗肝肿瘤的传统药物）与单独使用TACE动脉联合给药对治疗ACI大鼠肝细胞癌（HCC）的效果。方法：在30只雄性ACI大鼠中，在肝脏中进行了包膜下的固态莫里斯肝癌3 924A（2 mm〜3）植入。植入后第13天通过磁共振成像（MRI）测量肿瘤体积（V1）。在逆行导管插入后，通过胃十二指肠动脉注射以下不同的介入治疗药物（第14天），即（A）TACE（0.1 mg丝裂霉素+ 0.1 ml Lipiodol）+白let（1.0 mg）（n = 10）； （B）TACE +白let（1.0 mg）+结扎肝动脉（n = 10），（C）仅TACE（对照组，n = 10）。通过MRI（治疗后第13天）评估肿瘤体积（V2），并计算肿瘤生长率（V2 / V1）。结果：治疗前（V1）和治疗后（V2）的平均肿瘤体积在A组分别为0.0355 cm〜3和0.2248 cm〜3，B组分别为0.0374 cm〜3和0.0573 cm〜3，0.0380 cm〜3和0.3674 cm C组分别为〜3。 A组平均比（V2 / V1）为6.2791，B组为1.5324，C组为9.1382。与对照组（C组）相比，B组对肿瘤的生长有明显的抑制作用（P <0.01），而B组A没有（P＞ 0.05）。没有动物在植入过程中或术后死亡。结论：TACE与白术纹状动脉联合加结扎肝动脉比单独使用TACE治疗大鼠HCC更有效。

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