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首页> 外文期刊>World Journal of Gastroenterology >Epoxide hydrolase Tyr113 His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China
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Epoxide hydrolase Tyr113 His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China

机译：环氧水解酶Tyr113 His多态性与华北人群食管鳞状细胞癌易感性无关

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AIM: To investigate the possible association of microsomal epoxide hydrolase (mEH) Tyr113 His polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a population of North China. METHODS: The mEH Tyr113 His genotypes were determined by polymerase-chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 257 patients with esophageal squamous cell carcinoma (ESCC) and 252 healthy subjects as a control group. RESULTS: The frequencies for Tyr and His alleles were 44.2 %, 55.8 % in ESCC patients, and 44.0 % and 56.0 % in healthy subjects, respectively. No statistic difference in allele distribution was observed between ESCC patients and controls (χ~2=0.008, P=0.929). The overall genotype distribution difference was not observed between cancer cases and controls (χ~2=2.116, P=0.347). Compared with Tyr/Tyr genotype, neither His/His genotype nor in combination with Tyr/His genotype significantly modified the risk of the development of ESCC, the adjusted odds ratio was 1.076 (95 % CI=0.850-1.361) and 0.756 (95 % CI=0.493-1.157), respectively. When stratified for sex, age, smoking status and family history of upper gastrointestinal cancer, His/His genotype alone or in combination with Tyr/His genotype also did not show any significant influence on the risk of developing ESCC. CONCLUSION: MEH Tyr113His polymorphism may not be used as a stratification marker in screening individuals at a high risk of ESCC.
机译：目的：探讨中国北方人群中的微粒体环氧水解酶（mEH）Tyr113 His多态性与食管鳞状细胞癌（ESCC）易感性的关系。方法：采用聚合酶链反应（PCR）-限制性片段长度多态性（RFLP）分析法测定了257例食管鳞癌（ESCC）患者和252例健康受试者的mEH Tyr113 His基因型。结果：ESCC患者的Tyr和His等位基因频率分别为44.2％，55.8％和健康受试者的频率分别为44.0％和56.0％。 ESCC患者和对照组之间的等位基因分布没有统计学差异（χ〜2 = 0.008，P = 0.929）。在癌症病例和对照之间未观察到总体基因型分布差异（χ〜2 = 2.116，P = 0.347）。与Tyr / Tyr基因型相比，His / His基因型或与Tyr / His基因型组合均不能显着改变ESCC发生的风险，调整后的优势比为1.076（95％CI = 0.850-1.361）和0.756（95％）。 CI = 0.493-1.157）。当按性别，年龄，吸烟状况和上消化道癌的家族史进行分层时，单独的His / His基因型或与Tyr / His基因型联合使用的His / His基因型对发展ESCC的风险也没有显着影响。结论：MEH Tyr113His多态性不能作为分层标志物用于筛查高ESCC患者。

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