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首页> 外文期刊>World Journal of Gastroenterology >Characteristics and mechanism of enzyme secretion and increase in [Ca~(2+)]_i in Saikosaponin. (I) stimulated rat pancreatic acinar cells
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Characteristics and mechanism of enzyme secretion and increase in [Ca~(2+)]_i in Saikosaponin. (I) stimulated rat pancreatic acinar cells

机译：皂苷中[Ca〜（2 +）] _ i酶分泌增加的特征及机理。 （I）刺激大鼠胰腺腺泡细胞

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CONCLUSION: SA(I) is highly efficient in promoting the secretion of enzymes synthesized in rat pancreatic acini and raising intracellular [Ca~(2+)]_i. Signaling transduction pathway of SA(I) involves activating special membrane receptor and increase in cytoplasm [Ca~(2+)]_i sequentially. AIM: This investigation was to reveal the characteristics and mechanism of enzyme secretion and increase in [Ca~(2+)]_i stimulated by saikosaponin(I) [SA(I)] in rat pancreatic acini. METHODS: Pancreatic acini were prepared from male Wistar rats. Isolated acinar cells were suspended in Eagle's MEM solution. After adding drugs, the incubation was performed at 37℃ for a set period of time. Amylase of supematant was assayed using starch-iodide reaction.
机译：结论：SA（I）能有效促进大鼠胰腺腺泡中合成酶的分泌并提高细胞内[Ca〜（2 +）] _ i。 SA（I）的信号转导途径涉及激活特殊的膜受体并依次增加细胞质[Ca〜（2 +）] _ i。目的：揭示皂苷总皂苷（I）[SA（I）]刺激的大鼠胰腺腺泡中酶分泌和[Ca〜（2 +）] _ i增加的特征和机理。方法：从雄性Wistar大鼠制备胰腺腺泡。将分离的腺泡细胞悬浮在Eagle的MEM溶液中。加入药物后，在37℃下孵育一段时间。使用淀粉-碘化物反应测定上清液的淀粉酶。

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