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Activity of boanmycin against colorectal cancer

机译:博安霉素对大肠癌的活性

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Boanmycin (Bleomycin A6, BAM), a new antitumor antibiotic, was isolated from many components of blecomycin 9BLM) produced by streptomyces pingyangensis which were obtained froma soil sample collected in Pingyang County, Zhejiang Province, Chian. Boanmycin has a similar Chemical structure to that of BLM, but the terminal Amine moiety is different ~[1]. Pingyangmycin (bleomycin A5), one of multicomponent bleomycin complex produced by the strain, was found to have a high activity against a wide spectrum of murine transplantable tumors, but have a relatively low pulmonary toxicity in mice~[2-4].
机译:从平阳链霉菌生产的博来霉素9BLM的许多成分中分离出一种新的抗肿瘤抗生素波安霉素(Bleomycin A6,BAM),该成分是从中国浙江省平阳县采集的土壤样品中获得的。 Boanmycin具有与BLM类似的化学结构,但末端胺部分不同[〜1]。发现该菌株产生的多组分博来霉素复合物之一平阳霉素(博来霉素A5)对多种鼠类可移植肿瘤具有高活性,但对小鼠的肺毒性较低[2-4]。

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