Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication

Kong XB; Yang ZK; Liang LJ

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Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication

机译：P-糖蛋白在肝细胞癌中的过表达及其临床意义

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Most advanced hepatocellular garcinoma (HCC) is insensitive to most anticancer drugs which might be related to the high frequency of expression of the multidrug resistance-1 (MDR1) gene~[1] and its product, P-glycoprotein (P-gp). P-pg. P-gp expression may also be concerned wih tumor progression and differentiation. In the present study, we investgated P-gp expression and assessed the relationship between expression level of P-gp and the clinico-pathological parameters of HCC by immunohistochemistry in combination with computer-imaging analysis.

机译：大多数晚期肝细胞癌（HCC）对大多数抗癌药物不敏感，这可能与多药耐药性1（MDR1）基因〜[1]及其产物P-糖蛋白（P-gp）的高表达有关。页码P-gp表达也可能与肿瘤的进展和分化有关。在本研究中，我们研究了P-gp的表达，并通过免疫组织化学结合计算机成像分析评估了P-gp的表达水平与HCC临床病理参数之间的关系。

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来源
《World Journal of Gastroenterology》 |2000年第1期|p.134-135|共2页
作者
Kong XB; Yang ZK; Liang LJ;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
liver neoplasms; carcinoma; hepatocellular;

机译：肝肿瘤癌;肝细胞;

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1. SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro. [J] . Hur W, Rhim H, Jung CK, Carcinogenesis . 2010,第7期

机译：SOX4的过表达调节肝细胞癌中p53介导的细胞凋亡：体外临床意义和功能分析。
2. SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functionaln analysis in vitro [J] . Carcinogenesis . 2010,第7期

机译：SOX4的过表达调节肝细胞癌中p53介导的细胞凋亡：体外临床意义和功能分析
3. Correlation between clinical response to sorafenib in hepatocellular carcinoma treatment and polymorphisms of P-glycoprotein (ABCB1) and of breast cancer resistance protein (ABCG2): monocentric study [J] . Tandia Mahamadou, Mhiri Asma, Paule Bernard, Cancer chemotherapy and pharmacology. . 2017,第4期

机译：肝细胞癌治疗中索拉非尼的临床反应与乳突蛋白（ABCB1）多态性与乳腺癌抗性蛋白质（ABCG2）的相关性（ABCG2）：单眼研究
4. OVEREXPRESSION OF HEPATIC NF-KB AND ITS CLINICAL IMPLICATIONS IN HBV-RELATED HEPOTOCELLUIAR CARCINOMA [C] . Yao Dengfu, Wu Wei, Sai Wenli, The 6'th International Forum on Post-genome Technologies(6'IFPT)（第六届国际后基因组生命科学技术学术论坛） . 2009

机译：肝NF-κB在HBV相关肝细胞癌中的过表达及其临床意义
5. From Bedside to Bench-Side: The Clinical, Epidemiological and Molecular Basis for Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma [D] . Benhammou, Jihane . 2019

机译：从床边到台面：非酒精性脱脂性和肝细胞癌的临床，流行病学和分子基础
6. Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication [O] . Xian-Bing Kong, Zu-Kui Yang, Li-Jian Liang, 2000

机译：P-糖蛋白在肝细胞癌中的过表达及其临床意义
7. Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication [O] . 2015

机译：p-糖蛋白在肝细胞癌中的过度表达及其临床意义

Overexpression of P-glycoprotein in hepatocellular carcinoma and its clinical implication

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