Tumoricidal activation of murine resident peritoneal macrophages on pancreatic carcinoma by interleukin-2 and monoclonal antibodies

Qi Kui Chen; Shi Zhen Yuan; Zhi Yong Zeng

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Tumoricidal activation of murine resident peritoneal macrophages on pancreatic carcinoma by interleukin-2 and monoclonal antibodies

机译：白介素2和单克隆抗体对胰腺癌鼠常腹膜巨噬细胞的杀肿瘤活性

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摘要

Macrophages play an important role in tumor lysis and growth inhibition. They can be activated to a tumoricidal state by a variety of agents such as IFNr, TNFα or IL2. The killing machanisms of Activated macrophages have been extensively Investigated. Recently, it has been proved that Antibody dependent cellular cytotoxicity (ADCC) is One of the potent arms to lyse tumor cells resistant To cytotoxic macropages, and that the Antitumorous effect of a macrophage activator is Significantly augmented bythe combined use of MAbs capable of inducing ADCC to tumor cells~[3].

机译：巨噬细胞在肿瘤溶解和生长抑制中起重要作用。它们可以被多种试剂例如IFNτ，TNFα或IL2活化为杀肿瘤状态。广泛研究了活化巨噬细胞的杀灭机制。最近，已经证明抗体依赖性细胞毒性（ADCC）是裂解对细胞毒性巨噬细胞有抗性的肿瘤细胞的有效手段之一，并且巨噬细胞激活剂的抗肿瘤作用通过能够诱导ADCC的MAb的联合使用而显着增强。到肿瘤细胞〜[3]。

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来源
《World Journal of Gastroenterology》 |2000年第2期|p.287-289|共3页
作者
Qi Kui Chen; Shi Zhen Yuan; Zhi Yong Zeng;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
pancreatic neoplasms/ therapy; antibody; monoclonal/therapeutic use;

机译：胰腺肿瘤/治疗;抗体;单克隆/治疗用途;

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专利

1. Monoclonal antibody to murine gamma interferon inhibits lymphokine-induced antiviral and macrophage tumoricidal activities. [J] . G L Spitalny, E A Havell The Journal of Experomental Medicine . 1984,第5期

机译：鼠γ干扰素的单克隆抗体抑制淋巴因子诱导的抗病毒和巨噬细胞杀肿瘤活性。
2. Establishment of a hybridoma secreting a monoclonal antibody specific for activated tumoricidal macrophages. [J] . T Taniyama, T Watanabe The Journal of Experomental Medicine . 1982,第4期

机译：建立分泌对活化的肿瘤巨噬细胞具有特异性的单克隆抗体的杂交瘤。
3. Flow cytometric analysis of the effects exerted by monoclonal antibodies on binding and uptake of Leishmania mexicana subsp. mexicana promastigotes by murine peritoneal macrophages. [J] . K M Williams, J B Sacci, R L Anthony Infection and immunity . 1986,第1期

机译：流式细胞仪分析单克隆抗体对墨西哥利什曼原虫亚种结合和吸收的影响。小鼠腹膜巨噬细胞产生的墨西哥前鞭毛体。
4. Microdistribution of Fluorescently-labeled Monoclonal Antibody in a Peritoneal Dissemination model of Ovarian Cancer [C] . Nobuyuki kosaka, Mikako Ogawa, David S. Paik, Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications II . 2010

机译：荧光标记的单克隆抗体在卵巢癌腹膜扩散模型中的微分布。
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. Tumoricidal activation of murine resident peritoneal macrophages on pancreatic carcinoma by interleukin-2 and monoclonal antibodies [O] . Qi Kui Chen, Shi Zhen Yuan, Zhi Yong Zeng, 2000

机译：白介素2和单克隆抗体对胰腺癌鼠常腹膜巨噬细胞的杀肿瘤活性
7. Monoclonal antibody to murine gamma interferon inhibits lymphokine- induced antiviral and macrophage tumoricidal activities [O] . 1984

机译：鼠γ干扰素单克隆抗体抑制淋巴因子诱导的抗病毒和巨噬细胞杀肿瘤活性
8. Neutralization of Lymphokine-Mediated Antirickettsial Activity of Fibroblasts and Macrophages with Monoclonal Antibody Specific for Murine Interferon Gamma [R] . Jerrells, T. R., Turco, J., Winkler, H. H., 1986

机译：用小鼠干扰素γ特异性单克隆抗体中和淋巴因子介导的成纤维细胞和巨噬细胞抗小鼠活性

Tumoricidal activation of murine resident peritoneal macrophages on pancreatic carcinoma by interleukin-2 and monoclonal antibodies

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