Overexpression of p27~KIP1 induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell Line

Jiang Li Xin Ke Yang; Xin Xin Yu; Meng Liang Ge

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Overexpression of p27~KIP1 induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell Line

机译：p27〜KIP1的过度表达诱导了H_1-9204细胞株在G_1期的细胞周期阻滞和随后的凋亡

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AIM We have previously reported that inducible over-expression of Bak may prolong cell cycle in G_1 phase and lead to apoptosis in HCC-9204 cells. This study is to investigate whether p27~KIP1 plays An important role in this process. METHODS In order to elucidate the exact Function of p27~KIP1 in this process, a zinc inducible P27~KIP1 stable transfectant and transient p27~KIP1- GFP fusion transfectant were constructed. The Effects of inducible p27~KIP1 on cell growth, cell Cycle arrest and apoptosis were examined in the Mock, control pMD vector, and pMD-KIP1 Transfected HCC-9204 cells.

机译：目的我们以前曾报道过，诱导型Bak的过度表达可能会延长G_1期的细胞周期并导致HCC-9204细胞凋亡。本研究旨在探讨p27〜KIP1是否在此过程中发挥重要作用。方法为阐明p27〜KIP1在此过程中的确切功能，构建了锌诱导型P27〜KIP1稳定转染子和瞬时p27〜KIP1-GFP融合转染子。在模拟，对照pMD载体和pMD-KIP1转染的HCC-9204细胞中检测了诱导型p27〜KIP1对细胞生长，细胞周期停滞和凋亡的影响。

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来源
《World Journal of Gastroenterology》 |2000年第4期|p.513-521|共9页
作者
Jiang Li Xin Ke Yang; Xin Xin Yu; Meng Liang Ge;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
p27~KIP1; apoptosis; cell cycle;

机译：p27〜KIP1;细胞凋亡细胞周期;

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1. JS-K induces G(2)/M phase cell cycle arrest and apoptosis in A549 and H460 cells via the p53/p21(WAF1/CIP1) and p27(KIP1) pathways [J] . Song Zeqing, Yin Yongxin, Hao Siyuan, Oncology reports . 2019,第6期

机译：JS-K通过P53 / P21（WAF1 / CIP1）和P27（KIP1）途径在A549和H460细胞中诱导G（2）/ M期细胞周期停滞和凋亡
2. The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells. [J] . Dozio E, Ruscica M, Passafaro L, European Journal of Pharmacology: An International Journal . 2010,第1期

机译：天然抗氧化剂α-硫辛酸诱导MCF-7人乳腺癌细胞中p27（Kip1）依赖性细胞周期停滞和凋亡。
3. Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. [J] . Batsi C, Markopoulou S, Kontargiris E, Biochemical Pharmacology . 2009,第1期

机译：Bcl-2通过依赖p27（Kip1）依赖的G1 / S细胞周期阻滞与NF-κB激活一起阻断2-甲氧基雌二醇诱导的白血病细胞凋亡。
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Cannabinol Inhibits Proliferation and Induces Cell Cycle Arrest and Apoptosis in Glioblastoma, Hepatocellular Carcinoma and Breast Cancer Cells [D] . Zhong, Nuanying. 2020

机译：大麻素抑制胶质母细胞瘤，肝细胞癌和乳腺癌细胞中的增殖和诱导细胞周期停滞和凋亡
6. Overexpression of p27KIP1 induced cell cycle arrest in G1 phase and subsequent apoptosis in HCC-9204 cell line [O] . Jiang Li, Xin-Ke Yang, Xin-Xin Yu, 2000

机译：p27KIP1的过表达诱导了G1期的细胞周期停滞并随后在HCC-9204细胞株中发生了凋亡
7. BCR signals target p27(Kip1) and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells [O] . Banerji, L, Glassford, J, Lea, NC, 2001

机译：BCR通过PI3-K信号通路将靶标信号靶向p27（Kip1）和细胞周期蛋白D2，以介导WEHI 231 B细胞的细胞周期阻滞和凋亡

Overexpression of p27~KIP1 induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell Line

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