• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Bulletin of the National Research Centre >Evaluation of the Hepatoprotective Effect of Ginkgo Biloba Extract and its Comparison with Silymarin on Acute Hepatic Injury Caused in Rats by the Administration of Carbon Tetrachloride
【24h】

Evaluation of the Hepatoprotective Effect of Ginkgo Biloba Extract and its Comparison with Silymarin on Acute Hepatic Injury Caused in Rats by the Administration of Carbon Tetrachloride

机译：银杏叶提取物对四氯化碳给药对大鼠急性肝损伤的保护作用及与水飞蓟素的比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effect of Ginkgo biloba extract on acute liver injury caused by CCl_4 was studied and compared to that of silymarin in the rat. Ginkgo biloba at doses of 25 or 50 mg/kg or silymarin at dose of 22 mg/kg was given once daily orally for 15 days starting at time of CCl_4 administration. Ginkgo biloba at 50 mg/kg conferred significant protection against the hepatotoxic actions of CCl_4, reducing serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels to 39.6%, 46.8% and 33.1% of that of controls, respectively. In comparison, the elevated serum AST, ALT and ALP levels decreased to 28.4%, 45.1% and 34.2% of controls, respectively by 22 mg kg of silymarin. Histological examination showed marked decrease in centrilobular necrotic areas in rats treated with silymarin or ginkgo biloba. Rats treated with ginkgo biloba revealed more or less normal hepatocyte architecture. Stained sections were subjected to morphometric evaluation using computerised image analyzer. On image analysis, the area of damage was reduced by 34.8%, 65.5% by 25 or 50 mg/kg ginkgo biloba and by 89.2% by 22 mg/kg silymarin, respectively. The study suggests that administration of ginkgo biloba in a model of CCl_4 induced liver injury result in less liver damage. Ginkgo biloba might be of value in the therapy of chronic hepatitis.
机译：研究了银杏叶提取物对CCl_4引起的急性肝损伤的作用，并与水飞蓟素进行了比较。从施用CCl_4开始，每天口服一次，剂量为25或50 mg / kg的银杏叶或22 mg / kg的水飞蓟素，为期15天。 50 mg / kg的银杏叶对CCl_4的肝毒性作用具有显着保护作用，可将血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）的水平降低至对照组的39.6％，46.8％和33.1％ ， 分别。相比之下，22 mg kg水飞蓟素的血清AST，ALT和ALP升高水平分别降至对照组的28.4％，45.1％和34.2％。组织学检查显示，水飞蓟素或银杏叶处理过的大鼠的小叶中心坏死面积明显减少。用银杏叶治疗的大鼠或多或少显示出正常的肝细胞结构。使用计算机图像分析仪对染色的切片进行形态计量学评价。在图像分析中，银杏叶25毫克/千克和50毫克/千克减少了65.5％，水飞蓟素50毫克/千克减少了65.5％，水飞蓟素22毫克/千克减少了89.2％。研究表明，在CCl_4诱导的肝损伤模型中施用银杏叶可减少肝损伤。银杏叶在慢性肝炎的治疗中可能有价值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号