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首页> 外文期刊>Bulletin of the National Research Centre >Study on the Possible Oestrogenic Activity of Origanum majorana L. (Bardaqoush) Oil on Female Albino Rats
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Study on the Possible Oestrogenic Activity of Origanum majorana L. (Bardaqoush) Oil on Female Albino Rats

机译：大牛至油对雌性白化病大鼠可能致雌激素活性的研究

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摘要

The oestrogenic activity of Origanum majorana (O. majorana) oil was studied biologically by uterine weight and vaginal epithelium cornification method. A Significant increase in vaginal cornification and uterine weight was found in immature and overiectomized rats given O. majorana oil for five days orally. The immature and overiectomized rats after administration of Oestradiol in a dose 0.1 g /0.1 ml per day for 5 days also induce a significant increase in uterine weight and significant increase in vaginal cornification when compared by control groups. These results indicated that both doses of O. majorana oil (1 and 2 ml/ rat/day) have oestrogen like activity but less in activity from that of Oestradiol group. Concerning the effect of both O. majorana oil and Oestradiol on body weight it was found that there were nonsignificant changes from the initial body weight. These finding suggested that the O. majorana oil exerts an oestrogen like activity.
机译：通过子宫重量和阴道上皮角质化方法对牛至油的雌激素活性进行了生物学研究。在口服O.majorana油的未成熟和过度切除的大鼠中，发现其阴道角质化和子宫重量显着增加了五天。与对照组相比，每天以0.1 g / 0.1 ml的剂量服用雌二醇连续5天后，未成熟和切除过量的大鼠也引起子宫重量的显着增加和阴道角质形成的显着增加。这些结果表明，两种剂量的大麦o香精油（1和2 ml /大鼠/天）都具有类似雌激素的活性，但与雌二醇组相比活性较低。关于大麦香精油和雌二醇对体重的影响，发现与初始体重相比没有显着变化。这些发现表明，大果O.majorana油具有类似雌激素的活性。

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