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首页> 外文期刊>Bulletin of the National Research Centre >Chemical Constituents of Some Fungi and Their Antiviral Activity
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Chemical Constituents of Some Fungi and Their Antiviral Activity

机译：某些真菌的化学成分及其抗病毒活性

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摘要

The volatile constituents, as well as, the ether extracts of the two fungi Trichoderma harzianum Rifai and Trichoderma hamatum (Bon) Bain cultured in Weindling's medium were chemically and biologically investigated. GC/MS analysis of the volatile constituents revealed the identification of 29 and 34 components representing 76.41% and 87.82% of the total volatile constituents of T. harzianum and T. hamatum, respectively. cis-Calamenene followed by italicene, benzofuran and β-chamigrene were the major components of T. harzianum , while those of T. hamatum were cadinol tau followed by cubenol, globulol and α- cadinene. Four compounds were isolated from the ether extract of T. harzianum. They were identified by spectroscopic methods as a butenolide, scopo-rane, androstane derivative and fungisterol. Two compounds were isolated from T. hamatum., the first was identified as ethyl-15- methyl- hepta-decanoate and the second was found to be a mixture of three related compounds of hydroxy alkyl esters of octadecenoic acid. The volatile constituents and the ether extracts of the two fungi were evaluated for their activity as antiviral agents against HAV and Echovi-rus -9. The volatile constituents of the second fungus were found to be the most active.
机译：在Weindling培养基中培养的两种真菌哈茨木霉Rifai和哈茨木霉（Bon）Bain的挥发性成分以及醚提取物均经过化学和生物学研究。挥发性成分的GC / MS分析表明，鉴定出29种和34种成分，分别占哈茨木和哈密木总挥发性成分的76.41％和87.82％。哈萨克斯坦棉的主要成分是顺式-卡拉曼烯，其次是斜体，苯并呋喃和β-香米烯，而哈密木棉的主要成分是卡迪诺tau，其次是立方酚，球蛋白和α-卡丁烯。从哈茨木霉的醚提取物中分离出四种化合物。通过光谱法将它们鉴定为丁烯内酯，东香烷，雄烷烷衍生物和真菌甾醇。从金缕梅中分离出两种化合物，第一种被鉴定为-15-甲基-七癸酸乙酯，发现第二种为三种相关的十八烯酸羟烷基酯化合物的混合物。评价了两种真菌的挥发性成分和醚提取物作为抗HAV和Echovi-rus -9的抗病毒剂的活性。发现第二种真菌的挥发性成分最活跃。

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