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首页> 外文期刊>Journal of the Chemical Society of Pakistan >Chemical Constituents and Antiviral Activity from Marine Endophytic Fungi from Red Sea Alga Padina pavonica
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Chemical Constituents and Antiviral Activity from Marine Endophytic Fungi from Red Sea Alga Padina pavonica

机译：来自红海藻类帕迪纳Pavonica的海洋内生真菌的化学成分和抗病毒活性

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摘要

Three endophytic fungal strains, Fusarium equiseti, Scopulariopsis fusca and Geotrichum candidum were isolated from the inner tissue of the brown alga Padina pavonica, collected from the Red Sea. The organic extracts of their liquid cultures were evaluated for their inhibition of hepatitis C virus ( HCV) NS3-NS4A protease. As a result, F. equiseti showing a highlevel inhibition of HCV protease ( IC50 27.0 mu g/ ml) was selected for further investigation on its secondary metabolites. The fungus was identified by its morphology and 18S rDNA. Bioassayguided fractionation of the EtOAc extract of the fungus culture broth revealed seven known metabolites. The structures of these metabolites were determined by MS and NMR spectral analysis. The isolated compounds were explored for inhibition of HCV NS3-NS4A protease activity.
机译：从红海收集的棕榈藻氏藻氏帕科尼卡的内部组织中分离出三种内生真菌菌株，镰刀菌均衡菌株，镰刀菌均等，Scopulariopsis Fusca和Geotrichum Candidum。 评价其液体培养物的有机萃取物，抑制丙型肝炎病毒（HCV）NS3-NS4A蛋白酶。 结果，选择equiseti显示HCV蛋白酶的高抗凝胶抑制（IC5027.0μg/ ml）以进一步研究其次级代谢物。 通过其形态和18秒rDNA鉴定真菌。 真菌培养肉汤的EtOAc提取物的生物测定的分馏揭示了七种已知的代谢物。 通过MS和NMR光谱分析测定这些代谢物的结构。 探索了分离的化合物以抑制HCV NS3-NS4A蛋白酶活性。

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