Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

Guillaume Chouinard; Isabelle Clément; Julie Lafontaine; Francis Rodier; Estelle Schmitt

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Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

机译：CHK2在有丝分裂过程中在中心体的细胞周期依赖性定位

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Background Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers where numerous key regulators meet to control cell cycle progression. One of these factors involved in genome stability, the checkpoint kinase CHK2, was shown to localize at centrosomes throughout the cell cycle.

机译：背景技术中心体主要起微管组织中心的作用，并在有丝分裂过程中通过组织双极纺锤体发挥关键作用。除此功能外，中心体还充当反应中心，众多关键调节剂汇合在一起以控制细胞周期进程。这些参与基因组稳定性的因素之一，检查点激酶CHK2，在整个细胞周期中都位于中心体。

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《Cell Division》 |2013年第1期|1-12|共12页
作者
Guillaume Chouinard; Isabelle Clément; Julie Lafontaine; Francis Rodier; Estelle Schmitt;
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正文语种 eng
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关键词
CHK2 CHK1 Centrosome Mitosis Cell cycle;

机译：CHK2 CHK1中心体有丝分裂细胞周期;

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专利

1. Cell cycle-dependent localization of CHK2 at centrosomes during mitosis [J] . Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Cell Division . 2013,第1期

机译：CHK2在有丝分裂过程中在中心体的细胞周期依赖性定位
2. Cdc6 localizes to S- and G2-phase centrosomes in a cell cycle-dependent manner [J] . Kim Gwang Su, Kang Jeeheon, Bang Sung Woong, Biochemical and Biophysical Research Communications . 2015,第3期

机译：Cdc6以依赖细胞周期的方式定位于S相和G2相中心体
3. Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation. [J] . Zhao H, Traganos F, Albino AP, Cell cycle . 2008,第10期

机译：氧化应激诱导细胞周期依赖性Mre11募集，ATM和Chk2激活以及组蛋白H2AX磷酸化。
4. Dynamic Phosphorylation Regulates Histone Deacetylase Localization, Interactions, and Cell Cycle-dependent Functions [C] . Amanda J. Guise, Rommel A. Mathias, Todd M. Greco, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：动态磷酸化调节组蛋白脱乙酰酶定位，相互作用和细胞周期依赖性功能
5. The dynamic localization of Mob1 and its function in the regulation of the chromosomal passenger complex during mitosis and cytokinesis in mammalian cells. [D] . Wilmeth, Lori Jo. 2009

机译：Mob1的动态定位及其在哺乳动物细胞有丝分裂和胞质分裂过程中对染色体客体复合物的调控中的功能。
6. Cell cycle-dependent localization of CHK2 at centrosomes during mitosis [O] . Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, 2013

机译：CHK2在有丝分裂过程中在中心体的细胞周期依赖性定位
7. Cell cycle-dependent localization of CHK2 at centrosomes during mitosis [O] . Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, 2013

机译：CHK2在有丝分裂过程中在中心体的细胞周期依赖性定位

Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

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