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EMT or apoptosis: a decision for TGF-β

机译:EMT或细胞凋亡:TGF-β的决定

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摘要

Apoptosis and epithelial-to-mesenchymal transition (EMT) are very fundamental physiological processes. They are both independent and interrelated events in normal development and in maintaining body homeostasis. In recent years, EMT has emerged as a focus of studies in cancer research, and increasing data indicate that EMT functions as a central step in the invasion and metastasis of some tumor cells. Besides the cytoskeleton rearrangement and subsequent morphological changes, EMT is often characterized by the dissolution or attenuation of epithelial adhesion and other polarized structures, for example, tight junctions, and by accordingly the acquisition of migratory and invasive properties of the cells undergoing EMT. Along with these changes, EMT can be associated with transcrip-tional or expressional alterations of some epithelial and mesenchymal genes.
机译:凋亡和上皮-间质转化(EMT)是非常基本的生理过程。在正常发育和维持体内稳态方面,它们都是独立且相互关联的事件。近年来,EMT已成为癌症研究的重点,越来越多的数据表明EMT在某些肿瘤细胞的侵袭和转移中起着核心作用。除细胞骨架重排和随后的形态变化外,EMT的特征还通常在于上皮粘附和其他极化结构(例如紧密连接)的溶解或减弱,以及因此获得接受EMT的细胞的迁移和侵袭特性。随着这些变化,EMT可能与某些上皮和间质基因的转录或表达改变有关。

著录项

  • 来源
    《Cell Research》 |2007年第4期|p.289-290|共2页
  • 作者

    Jianguo Song;

  • 作者单位

    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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