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Side effects of Tamiflu: clues from an Asian single nucleotide polymorphism

机译：达菲的副作用：亚洲单核苷酸多态性的线索

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摘要

Tamiflu (Oseltamivir phosphate) seems to be a double-edged sword to some in Asia. While it is counted on against influenza and a feared avian influenza pandemic [1], the drug is also associated with side effects, ranging from neu-ropsychiatric, gastrointestinal, to hyperthermia and skin problems. According to a document from US Food and Drug Administration in 2005 [2], 1184 cases of side effects have been reported. Interestingly 69 out of the 75 pediatric cases were from Japan, including two teen suicides. The situation seemed to have made a gloomier turn recently. It was reported in February, 2007 that two Japanese teenagers jumped from apartment buildings after taking Tamiflu and died, bringing the total number of deaths after taking Tamiflu in Japan to 54 [3,4]. Although no direct causal relationship had been established yet, the Japan Health Ministry warned doctors about giving the drug to teenagers. In comparison, relatively few cases of severe side effects were reported from America and European countries [5]. What is wrong with this picture? It has concerned and bewildered many. The pages in this issue [6] offer one fascinating hypothesis that tries to explain the mystery using an integrated approach combining structural bioinformatic analysis and enzyme assays.
机译：达菲（磷酸奥司他韦）似乎是亚洲一些人的双刃剑。尽管该药被认为可以抵抗流感和令人担忧的禽流感大流行[1]，但它也具有副作用，从神经精神病学，胃肠道疾病到热疗和皮肤问题不等。根据2005年美国食品和药物管理局的文件[2]，已经报告了1184例副作用。有趣的是，在75例儿科病例中，有69例来自日本，其中包括两名青少年自杀。最近这种情况似乎转为阴沉。据报道，2007年2月，两名日本青少年在服用达菲后从公寓楼跳下身亡，使在日本服用达菲后的死亡总数达到54 [3,4]。尽管尚未建立直接的因果关系，但日本厚生省警告医生不要将药物给予青少年。相比之下，美国和欧洲国家报道的严重副作用病例相对较少[5]。这幅画怎么了？它使许多人感到困惑。本期[6]中的页面提供了一个令人着迷的假说，该假说试图使用结合了结构生物信息学分析和酶分析的集成方法来解释这个奥秘。

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  • 来源
    《Cell Research》 |2007年第4期|309-310|共2页
  • 作者

    Manyuan Long;

  • 作者单位

    Department of Ecology and Evolution, The University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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