• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell Research >Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
【24h】

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know

机译：粒细胞巨噬细胞集落刺激因子（GM-CSF）和T细胞反应：我们做什么和不知道

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. Recent intensive investigations are centered on the application of GM-CSF as an immune adjuvant for its ability to increase dendritic cell (DC) maturation and function as well as macrophage activity. It is used clinically to treat neutropenia in cancer patients undergoing chemotherapy, in AIDS patients during therapy, and in patients after bone marrow transplantation. Interestingly, the hematopoietic system of GM-CSF-deficient mice appears to be normal; the most significant changes are in some specific T cell responses. Although molecular cloning of GM-CSF was carried out using cDNA library of T cells and it is well known that the T cells produce GM-CSF after activation, there is a lack of systematic investigation of this cytokine in production by T cells and its effect on T cell function. In this article, we will focus mainly on the immunobiology of GM-CSF in T cells.
机译：粒细胞巨噬细胞集落刺激因子（GM-CSF）是重要的造血生长因子和免疫调节剂。 GM-CSF对各种循环白细胞的功能活性也具有深远的影响。它在接受免疫刺激后由多种细胞类型产生，包括T细胞，巨噬细胞，内皮细胞和成纤维细胞。尽管GM-CSF是本地生产的，但它可以旁分泌的方式募集循环中的中性粒细胞，单核细胞和淋巴细胞，以增强它们在宿主防御中的功能。最近的深入研究集中在应用GM-CSF作为免疫佐剂，因为它具有增强树突状细胞（DC）成熟和功能以及巨噬细胞活性的能力。它在临床上用于治疗接受化疗的癌症患者，治疗期间的AIDS患者以及骨髓移植后的患者的中性粒细胞减少。有趣的是，缺乏GM-CSF的小鼠的造血系统似乎是正常的。最明显的变化是在某些特定的T细胞反应中。尽管使用T细胞的cDNA文库进行了GM-CSF的分子克隆，并且众所周知T细胞在活化后会产生GM-CSF，但仍缺乏对该T细胞产生的细胞因子及其作用的系统研究在T细胞功能上。在本文中，我们将主要关注GM-CSF在T细胞中的免疫生物学。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号