Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor

Lin Leng; Richard Bucala

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Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor

机译：通过克隆细胞表面受体揭示对巨噬细胞迁移抑制因子（MIF）生物学的洞察力

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The recent cloning of MIF receptor fills an important gap in our understanding of the molecular biology and immunology of MIF. The MIF receptor, like MIF, does not fall into any established family of protein mediators, providing both new challenges and opportunities for the structural and functional analysis of MIF signal transduction.

机译：MIF受体的最新克隆填补了我们对MIF分子生物学和免疫学认识的重要空白。 MIF受体与MIF一样，不属于任何已建立的蛋白质介体家族，这为MIF信号转导的结构和功能分析提供了新的挑战和机遇。

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来源
《Cell Research》 |2006年第2期|p.162-168|共7页
作者
Lin Leng; Richard Bucala;
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作者单位

Departments of Medicine and Pathology, Yale University School of Medicine, The Anlyan Center, S525, 300 Cedar Street, New Haven CT 06520-8056, USA;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
MIF; MIF receptor; ERK-1/2;

机译：MIF;MIF受体;ERK-1 / 2;

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专利

1. Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor. [J] . Leng L, Bucala R Cell research. . 2006,第2期

机译：通过克隆其细胞表面受体揭示了对巨噬细胞迁移抑制因子（MIF）生物学的洞察力。
2. Receptor Binding and Cellular Uptake Studies of Macrophage Migration Inhibitory Factor (MIF): Use of Biologically Active Labeled MIF Derivatives. [J] . Kleemann R, Grell M, Mischke R, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2002,第3期

机译：巨噬细胞迁移抑制因子（MIF）的受体结合和细胞摄取研究：使用生物活性标记的MIF衍生物。
3. Macrophage Receptors for Migration Inhibitory Factor (MIF), Migration Stimulatory Factor (MSF), and Agglutinating Factor [J] . Douglas S. Gregory, Joseph D. Feldman, Roy A. Fox The journal of immunology . 1974,第5期

机译：巨噬细胞受体的迁移抑制因子（MIF），迁移刺激因子（MSF）和凝集因子。
4. Macrophage inhibitory factor (MIF) and tumor necrosis factor a (TNFa) release in primary neonatal rat cardiac myocytes depends on the inflammatory stimulus [C] . B. Donner, M. Harjes, G. Emmerichs, Nordrhein-Westfa?lische Akademie der Wissenschaften . 2005

机译：巨噬细胞抑制因子（MIF）和肿瘤坏死因子A（TNFA）在原发性新生大鼠心肌细胞中释放取决于炎症刺激
5. Role of the cytokine Macrophage Migration Inhibitory Factor (MIF) in inner ear neuronal and sensory cell development. [D] . Ebisu, Fumi. 2010

机译：细胞因子巨噬细胞迁移抑制因子（MIF）在内耳神经元和感觉细胞发育中的作用。
6. A Tautomerase-Null Macrophage Migration-Inhibitory Factor (MIF) Gene Knock-In Mouse Model Reveals That Protein Interactions and Not Enzymatic Activity Mediate MIF-Dependent Growth Regulation [O] . Günter Fingerle-Rowson, Dayananda Rao Kaleswarapu, Corinna Schlander, 2010

机译：一个互变异构酶-空巨噬细胞迁移抑制因子（MIF）基因敲入小鼠模型揭示蛋白质相互作用和非酶活性介导MIF依赖性生长调节。
7. MECHANISM OF ACTION OF MIGRATION INHIBITORY FACTOR (MIF) : I. EVIDENCE FOR A RECEPTOR FOR MIF PRESENT ON THE PERITONEAL MACROPHAGE BUT NOT ON THE ALVEOLAR MACROPHAGE [O] . Leu, Richard W., Eddleston, A. L. W. F., Hadden, John W., 1972

机译：迁移抑制因子（MIF）的作用机理：I.存在于腹膜巨噬细胞但不是在肺泡巨噬细胞上的MIF受体的证据

Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor

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