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GSK-3β as a driving force in ovarian cancer

机译：GSK-3β作为卵巢癌的驱动力

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摘要

Ovarian cancer is one of the most lethal malignancies in women. Identification of new therapeutic targets would provide opportunities for developing potentially more effective treatment regimes. In the July issue of Cell Research, Cao et al. reports that glycogen synthase kinase-3β (GSK-3β) plays an important role in positively regulating the proliferation of human ovarian cancer cells, and thus it may represent such a target. GSK-3β is a serine/threonine kinase that is known to be involved in regulation of β-catenin signaling, where it participates in the formation of a multi-component destruction complex that promotes the phosphorylation and subsequent degradation of β-catenin. Given that overactive β-catenin signaling is involved in many forms of human cancer, this classic mode of GSK-3β action should qualify it as a "tumor suppressor". Intriguingly, however, two recent studies have implicated that GSK-3β may actually play a pro-tumor role in pancreatic and colorectal cancers. Since ovarian tumors often exhibit increased expression of GSK-3β, these recent findings prompted Cao et al. to examine the potential role of GSK-3β in ovarian cancer cells.
机译：卵巢癌是女性中最致命的恶性肿瘤之一。确定新的治疗目标将为开发潜在更有效的治疗方案提供机会。在《细胞研究》杂志的七月号中，曹等人。报道了糖原合酶激酶3β（GSK-3β）在积极调节人卵巢癌细胞的增殖中起重要作用，因此可能代表了这一目标。 GSK-3β是一种丝氨酸/苏氨酸激酶，已知参与β-catenin信号的调节，在其中它参与形成多组分破坏复合物，该复合物促进β-catenin的磷酸化和随后的降解。考虑到过度活跃的β-catenin信号传导参与多种形式的人类癌症，这种经典的GSK-3β作用模式应使其成为“肿瘤抑制因子”。然而，有趣的是，两项最新研究表明，GSK-3β可能实际上在胰腺癌和大肠癌中发挥了促肿瘤作用。由于卵巢肿瘤通常表现出GSK-3β的表达增加，这些最新发现促使Cao等人提出。检查GSK-3β在卵巢癌细胞中的潜在作用。

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  • 来源
    《Cell Research》 |2006年第7期|p.609|共1页
  • 作者

    Dangsheng Li;

  • 作者单位

    Cell Research, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 319 Yueyang Road, Shanghai 200031, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

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