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首页> 外文期刊>Cell Research >Glycogen synthase kinase-3β positively regulates the proliferation of human ovarian cancer cells
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Glycogen synthase kinase-3β positively regulates the proliferation of human ovarian cancer cells

机译：糖原合酶激酶3β积极调节人卵巢癌细胞的增殖

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Although glycogen synthase kinase-3 (GSK-3) might act as a tumor suppressor since its inhibition is expected to mimic the activation of Wnt-signaling pathway, GSK-3β may contribute to NF-κB activation in cancer cells leading to increased cancer cell proliferation and survival. Here we report that GSK-3β activity was involved in the proliferation of human ovarian cancer cell both in vitro and in vivo. Inhibition of GSK-3 activity by pharmacological inhibitors suppressed proliferation of the ovarian cancer cells. Overexpressing constitutively active form of GSK-3β induced entry into the S phase, increased cyclin D1 expression and facilitated the proliferation of ovarian cancer cells. Furthermore, GSK-3 inhibition prevented the formation of the tumor in nude mice generated by the inoculation of human ovarian cancer cells. Our findings thus suggest that GSK-3β activity is important for the proliferation of ovarian cancer cells, implicating this kinase as a potential therapeutic target in ovarian cancer.
机译：尽管糖原合酶激酶3（GSK-3）可能起肿瘤抑制作用，因为它的抑制作用有望模拟Wnt信号通路的激活，但GSK-3β可能有助于癌细胞中NF-κB的活化，从而导致癌细胞增加增殖和生存。在这里，我们报道GSK-3β活性在体外和体内均参与人卵巢癌细胞的增殖。药理抑制剂抑制GSK-3活性可抑制卵巢癌细胞的增殖。 GSK-3β的过表达组成型活性形式诱导进入S期，细胞周期蛋白D1表达增加，并促进卵巢癌细胞的增殖。此外，GSK-3抑制作用阻止了人卵巢癌细胞接种产生的裸鼠肿瘤的形成。因此，我们的发现表明，GSK-3β活性对于卵巢癌细胞的增殖很重要，暗示该激酶是卵巢癌的潜在治疗靶标。

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