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首页> 外文期刊>Cell Research >The tumor-selective over-expression of the human Hsp 70 gene is at-tributed to the aberrant controls at both initiation and elongation levels f of transcription
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The tumor-selective over-expression of the human Hsp 70 gene is at-tributed to the aberrant controls at both initiation and elongation levels f of transcription

机译：人类Hsp 70基因的肿瘤选择性过表达在转录的起始和延伸水平f均归因于异常对照

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The tumor selective over-expression of the human Hsp70 gene has been well documented in human tumors, linked to the poor prognosis, being refractory to chemo- and radio-therapies as well as the advanced stage of tumorous lesions in particular. However, both the nature and details of aberrations in the control of the Hsp70 expression in tumor remain enigmatic. By comparing various upstream segments of the Hsp70 gene for each's ability to drive the luciferase reporter genes in the context of the tumor cell lines varying in their p53 status and an immortal normal liver cell line, we demonstrated in a great detail the defects in the control mechanisms at the both initiation and elongation levels of transcription being instrumental to the tumor selective profile of its expression. Our data should not only offer new insights into our understanding of the tumor specific over-expression of the human Hsp70 gene, but also paved the way for the rational utilization of the tumor selective mechanism with the Hsp70 at the central stage for targeting the therapeutic gene expression to human tumors.
机译：人Hsp70基因的肿瘤选择性过表达已在人肿瘤中得到充分证明，与预后不良有关，对化学疗法和放射疗法难以治疗，尤其是肿瘤病变的晚期。然而，在肿瘤中控制Hsp70表达的像差的性质和细节仍然令人费解。通过比较Hsp70基因的各个上游区段在不同的p53状态肿瘤细胞系和永生正常肝细胞系的背景下驱动荧光素酶报告基因的能力，我们非常详细地证明了对照中的缺陷在转录的起始和延伸水平上的机制对于其表达的肿瘤选择性特征是重要的。我们的数据不仅应该为我们对人类Hsp70基因的肿瘤特异性过度表达的理解提供新的见解，而且应为以Hsp70为中心靶向治疗基因的肿瘤选择性机制的合理利用铺平道路。表达于人类肿瘤。

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