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Kinetics of thymocyte developmental process in fetal and neonatal mice

机译：胎儿和新生小鼠胸腺细胞发育过程的动力学

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Kinetics of thymocyte development in vivo during embryogenesis was pursued. The early development of thymocytes in the fetal and neonatal BALB/c mice was discontinuous, with four waves of cell proliferation occurring at fetal day (Fd) 14 to 17, Fd 18 to day (D) 1 after birth, D 2 to D 5 and D6 thereafter. The first three proliferation waves coincided with the generation of CD4~(hi)CD8~(hi) (DP), TCR~+CD4~(hi)CD8~(-/lo) (CD4 SP), and TCR~+CD4~(-/lo)CD8~(int/hi)(CD8 SP) thymocytes, respectively. The transition from DN to DP cells was further investigated and it was found out that there were two differential pathways via immature single positive (ISP) cells in the BALB/c mice, each functioning at different fetal ages. One is via TCR~-CD4~-CD8~+ cells, occurring between Fd 15 and Fd 17 and the other is via TCR~-CD4~+CD8~- cells, occurring from Fd 17 until birth. In contrast, the TCR~-CD4~-CD8~+ pathway dominated overwhelmingly in the C57BL/6 mice. These findings shed new light on the hypothesis that the differential pathway preference varies with mouse strains. With respect to the shift in the intensity of CD4 and CD8 expression on thymocytes from fetal to adult mice, the TCR~+CD4~(hi)CD8~(-/lo), and TCR~+CD4~(-/lo)CD8~(int/hi) subsets might be equivalent to the medullary type TCR~+CD4/CD8 SP cells.
机译：追求体内胚胎发生过程中胸腺细胞发育的动力学。胎儿和新生BALB / c小鼠的胸腺细胞早期发育是不连续的，在胎儿出生后第14至17天，出生后1至18天，第2至第5天发生了四波细胞增殖波。然后是D6。前三个扩散波与CD4〜（hi）CD8〜（hi）（DP），TCR〜+ CD4〜（hi）CD8〜（-/ lo）（CD4 SP）和TCR〜+ CD4〜的产生同时发生。 （-/ lo）CD8〜（int / hi）（CD8 SP）胸腺细胞。进一步研究了从DN到DP细胞的转变，发现BALB / c小鼠中有两种通过未成熟单阳性（ISP）细胞的差异途径，每条途径均在不同的胎儿年龄发挥作用。一种是通过Fd 15和Fd 17之间发生的TCR--CD4--CD8- +细胞发生，另一种是通过Fd 17发生直至出生的TCR--CD4-+ CD8-细胞。相反，在C57BL / 6小鼠中，TCR〜-CD4〜-CD8〜+途径占绝对优势。这些发现为不同途径偏好随小鼠品系而变化的假设提供了新的依据。关于从胎儿到成年小鼠的胸腺细胞上CD4和CD8表达强度的变化，TCR〜+ CD4〜（hi）CD8〜（-/ lo）和TCR〜+ CD4〜（-/ lo）CD8 〜（int / hi）子集可能等同于髓样TCR〜+ CD4 / CD8 SP细胞。

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