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Msx homeobox gene family and craniofacial development

机译:Msx同源盒基因家族与颅面发育

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摘要

Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the pheno-typic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice.
机译:脊椎动物Msx基因是未链接的含同源异形盒的基因,与果蝇肌肉片段同源异形盒基因具有同源性。这些基因在脊椎动物胚胎发育过程中在组织与组织相互作用的多个位点表达。由Msx基因介导的诱导性相互作用对于正常颅面,肢体和外胚层器官的形态发生是必不可少的,并且对于小鼠的存活也是必不可少的,这在基因敲除小鼠和人类中表现出的表型异常即可证明。这篇综述总结了与人类和小鼠颅面发育有关的Msx基因的表达,调控和功能分析。

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