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首页> 外文期刊>Cell and Tissue Research >BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system
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BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system

机译：BMP是再生肌肉骨骼系统组织串扰中的介体

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The musculoskeletal system is a tight network of many tissues. Coordinated interplay at a biochemical level between tissues is essential for development and repair. Traumatic injury usually affects several tissues and represents a large challenge in clinical settings. The current demand for potent growth factors in such applications thus accompanies the keen interest in molecular mechanisms and orchestration of tissue formation. Of special interest are multitasking growth factors that act as signals in a variety of cell types, both in a paracrine and in an autocrine manner, thereby inducing cell differentiation and coordinating not only tissue assembly at specific sites but also maturation and homeostasis. We concentrate here on bone morphogenetic proteins (BMPs), which are important crosstalk mediators known for their irreplaceable roles in vertebrate development. The molecular crosstalk during embryonic musculoskeletal tissue formation is recapitulated in adult repair. BMPs act at different levels from the initiation to maturation of newly formed tissue. Interestingly, this is influenced by the spatiotemporal expression of different BMPs, their receptors and co-factors at the site of repair. Thus, the regenerative potential of BMPs needs to be evaluated in the context of highly connected tissues such as muscle and bone and might indeed be different in more poorly connected tissues such as cartilage. This highlights the need for an understanding of BMP signaling across tissues in order to eventually improve BMP regenerative potential in clinical applications. In this review, the distinct members of the BMP family and their individual contribution to musculoskeletal tissue repair are summarized by focusing on their paracrine and autocrine functions.
机译：肌肉骨骼系统是许多组织的紧密网络。组织之间在生化水平上协调的相互作用对于发育和修复至关重要。创伤性损伤通常会影响多个组织，在临床环境中是一项巨大的挑战。因此，在此类应用中当前对有效生长因子的需求伴随着对分子机制和组织形成的协调的强烈兴趣。特别令人关注的是多任务生长因子，它以旁分泌和自分泌的方式在多种细胞类型中充当信号，从而诱导细胞分化并不仅协调特定部位的组织组装，而且还协调成熟和体内稳态。我们在此集中讨论骨形态发生蛋白（BMP），它们是重要的串扰介体，因其在脊椎动物发育中具有不可替代的作用而闻名。在成年修复中概括了胚胎肌肉骨骼组织形成过程中的分子串扰。从新形成的组织开始到成熟，BMP发挥不同的作用。有趣的是，这受修复部位不同BMPs，其受体和辅因子的时空表达影响。因此，需要在高度连接的组织（例如肌肉和骨骼）的背景下评估BMP的再生潜力，而在连接较差的组织（例如软骨）中的确可能有所不同。这突显了对跨组织BMP信号传导的理解的需求，以便最终提高临床应用中BMP的再生潜力。在这篇综述中，BMP家族的不同成员及其在肌肉骨骼组织修复中的个人贡献归因于它们的旁分泌和自分泌功能。

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