NF-κB and STAT3 signaling hubs for lung innate immunity

Lee J. Quinton; Joseph P. Mizgerd

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NF-κB and STAT3 signaling hubs for lung innate immunity

机译：NF-κB和STAT3信号枢纽对肺的先天免疫力

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Innate immune responses to lung pathogens involve the coordinated expression of myriad affector and effector molecules of innate immunity, which must be induced and appropriately regulated in response to diverse stimuli generated by microbes or the infected host. Many intercellular and intracellular signaling pathways are involved, but we propose NF-κB and STAT3 transcription factors to be especially important signaling hubs for integrating these pathways to orchestrate effective host defense without excessive inflammatory injury.

机译：对肺部病原体的先天免疫应答涉及先天免疫的多种效应子和效应子分子的协同表达，必须响应微生物或感染宿主产生的各种刺激来诱导和适当调节先天免疫力。涉及许多细胞间和细胞内信号传导途径，但我们认为NF-κB和STAT3转录因子是特别重要的信号传导枢纽，用于整合这些途径以协调有效的宿主防御而不会引起过度的炎性损伤。

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《Cell and Tissue Research》 |2011年第1期|p.153-165|共13页
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Lee J. Quinton; Joseph P. Mizgerd;
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1. NF-kappaB and STAT3 signaling hubs for lung innate immunity. [J] . Quinton LJ, Mizgerd JP Cell and Tissue Research . 2011,第1期

机译：NF-kappaB和STAT3信号枢纽，可用于肺部先天免疫。
2. Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells [J] . Flavia A. Wald, Radia Forteza, Pedro J. Salas, Biology Open . 2013,第12期

机译：Par-复杂的aPKC和Par3与上皮细胞的先天免疫NF-κB通路相互干扰Par-复杂的aPKC和Par3与上皮细胞的先天免疫NF-κB通路相互干扰上皮细胞中与先天免疫NF-βoB通路的相互作用
3. Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells Par-complex aPKC and Par3 cross-talk with innate immunity NF-???oB pathway in epithelial cells [J] . Flavia A. Wald, Radia Forteza, Pedro J. Salas, Biology Open . 2013,第11期

机译：Par-复杂的aPKC和Par3与上皮细胞的先天免疫NF-κB通路相互干扰Par-复杂的aPKC和Par3与上皮细胞的先天免疫NF-κB通路相互干扰上皮细胞中与先天免疫NF-βoB通路的相互作用
4. MODULAR CONTROL OF INNATE IMMUNE SIGNALING USING SELF-ASSEMBLY OF IMMUNE SIGNALS [C] . Christopher M. Jewell Nanotechnology in medicine II: briding translational in vitro and in vivo interfaces . 2018

机译：使用免疫信号的自组装对初始免疫信号进行模块化控制
5. Role of NF-κB/Rel proteins in mediating innate immune responses in Drosophila melanogaster [D] . Pal, Subhamoy 2006

机译：NF-κB/ Rel蛋白在介导果蝇中固有免疫反应中的作用
6. IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis [O] . Julia Bollrath, Florian R. Greten 2009

机译：IKK /NF-κB和STAT3途径：炎症介导的肿瘤促进和转移中的中心信号枢纽
7. IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis [O] . Bollrath, Julia, Greten, Florian R. 2009

机译：IKK /NF-κB和STAT3途径：炎症介导的肿瘤促进和转移中的中心信号枢纽

NF-κB and STAT3 signaling hubs for lung innate immunity

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