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首页> 外文期刊>Cell and Tissue Research >Cell organization of the rat pars tuberalis. Evidence for open communication between pars tuberalis cells, cerebrospinal fluid and tanycytes
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Cell organization of the rat pars tuberalis. Evidence for open communication between pars tuberalis cells, cerebrospinal fluid and tanycytes

机译：大鼠的细胞组织是结节。腮腺细胞，脑脊液和单核细胞之间开放交流的证据

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摘要

The pars tuberalis (PT) is the only pituitary region in close contact with the medial-basal hypothalamus and bathed by cerebrospinal fluid (CSF). Although PT has long been recognized as an endocrine gland, certain aspects of its structure remain obscure. The present investigation has been designed to gain information concerning (1) the cellular organization of PT, (2) the PT/median eminence spatial relationship and (3) the exposure of various cell compartments of PT to CSF. Non-endocrine cells (S100-reactive) appear as the organizer of the PT architecture. The apical poles of these cells line large cistern-like cavities and the processes of these cells establish a close spatial relationship with PT-specific secretory cells, portal capillaries and tanycytes. The cisterns are also endowed with clusters of ciliated cells and with a highly electron-dense and PAS-reactive content. The unique spatial organization of endocrine and non-endocrine cells of the PT supports a functional relationship between both cell populations. PT endocrine cells display a hallmark of PT-specific cells, namely, the paranuclear spot, which is a complex structure involving the Golgi apparatus, a large pool of immature secretory granules and a centriole from which originates a single 9+0 cilium projecting to the intercellular channels. Horseradish peroxidase (HRP) injected into the CSF readily reaches the intercellular channels of PT and the inner channel of the single cilium and is incorporated by the endocytic machinery of the secretory cells. The PT endocrine cells, through their single 9+0 cilium, may act as sensors of the CSF. HRP also reaches the lumen of the cisterns, indicating that this PT compartment is also exposed to CSF. PT endocrine cells establish direct cell-to-cell contacts with hypothalamic β1 tanycytes, suggesting a second means of brain-PT communication. Keywords Pars tuberalis - Ultrastructure - Immunocytochemistry - Endocrine cells - Non-endocrine cells - Cerebrospinal fluid - Tanycytes - Rat (Sprague Dawley, male) This work was supported by grants from DID and MECESUP of Universidad Austral to M.G and a grant from Fondecyt no. 1070241, Chile, to E.M.R.
机译：腮腺（PT）是唯一与内侧基底下丘脑紧密接触并被脑脊液（CSF）沐浴的垂体区域。尽管PT长期以来一直被认为是内分泌腺，但其结构的某些方面仍然不清楚。本研究旨在获取有关以下方面的信息：（1）PT的细胞组织，（2）PT /中位突出空间关系，以及（3）PT的各个细胞区室暴露于CSF。非内分泌细胞（对S100有反应性）似乎是PT体系结构的组织者。这些细胞的顶端排列着大的水箱样腔，这些细胞的过程与PT特异性分泌细胞，门静脉毛细血管和单核细胞建立了紧密的空间关系。储水池还具有纤毛细胞簇，并具有高度的电子致密性和PAS反应性。 PT的内分泌和非内分泌细胞的独特空间组织支持两种细胞群之间的功能关系。 PT内分泌细胞具有PT特异性细胞的特征，即核旁斑点，这是一个涉及高尔基体的复杂结构，有大量未成熟分泌颗粒和一个中心粒，从该中心产生单个9 + 0纤毛投射到细胞间通道。注入脑脊液的辣根过氧化物酶（HRP）可以很容易地到达PT的细胞间通道和单个纤毛的内部通道，并通过分泌细胞的内吞机制被整合。 PT内分泌细胞通过其单个9 + 0纤毛可以充当CSF的传感器。 HRP也到达水箱内腔，表明该PT隔室也暴露于CSF。 PT内分泌细胞与下丘脑β 1 tanycytes建立直接的细胞间接触，提示了脑PT交流的第二种方法。关键词Pars tuberalis-超微结构-免疫细胞化学-内分泌细胞-非内分泌细胞-脑脊液-单核细胞-大鼠（Sprague Dawley，男）这项工作得到了南方大学DID和MECESUP授予M.G和Fondecyt no。智利1070241，变更为E.M.R.

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