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首页> 外文期刊>Cell and Tissue Research >Glial cells revealed by GFAP immunoreactivity in fish gut
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Glial cells revealed by GFAP immunoreactivity in fish gut

机译：鱼肠中GFAP免疫反应揭示的胶质细胞

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摘要

Glial fibrillary acidic protein (GFAP) is a commonly used marker to identify enteric glia in the mammalian gut. Little is however known about enteric glia in other vertebrates. The aim of the present study was to examine the distribution of GFAP immunoreactivity in adult and developing fish. In adult shorthorn sculpin (Myoxocephalus scorpius) and zebrafish (Danio rerio), GFAP immunoreactivity was seen in the myenteric plexus in all regions of the gut. Co-staining for the neuronal markers Hu C/D and acetylated tubulin showed that GFAP immunoreactivity was not associated with nerves. GFAP immunoreactivity was predominantly seen in processes with few glial cell bodies being demonstrated in adult fish. GFAP immunoreactivity was also found in the gut in larval zebrafish from 3 days post-fertilisation, i.e. at approximately the same time that differentiated enteric nerve cells first occur. Immunoreactivity was most prominent in areas with no or a low density of Hu-immunoreactive nerve cell bodies, indicating that the developing glia follows a different pattern from that of enteric neurons. The results suggest that GFAP can be used as a marker for enteric glia in fish, as in birds and mammals. The distribution of GFAP immunoreactivity implies that enteric glia are widespread in the fish gastrointestinal tract. Glia and neurons diverge early during development of the gastrointestinal tract.
机译：胶质纤维酸性蛋白（GFAP）是鉴定哺乳动物肠道中肠神经胶质的常用标记。然而，对其他脊椎动物的肠神经胶质知之甚少。本研究的目的是检查成年和发育中鱼的GFAP免疫反应性分布。在成年的短角（Myoxocephalus scorpius）和斑马鱼（Danio rerio）中，在肠道的所有区域的肌间神经丛中都观察到了GFAP免疫反应性。对神经元标记物Hu C / D和乙酰化微管蛋白的共同染色显示，GFAP免疫反应性与神经无关。 GFAP免疫反应性主要出现在成年鱼中，几乎没有神经胶质细胞体。受精后3天，即在分化的肠神经细胞首次出现的大约同一时间，在幼虫斑马鱼的肠中也发现了GFAP免疫反应性。免疫反应性在没有Hu免疫反应性神经细胞体或密度低的区域最为突出，这表明发育中的神经胶质细胞与肠道神经元具有不同的模式。结果表明，GFAP可以用作鱼类和鸟类以及哺乳动物中肠神经胶质的标志物。 GFAP免疫反应性的分布表明肠胶质细胞在鱼的胃肠道中广泛分布。胶质细胞和神经元在胃肠道发育的早期分化。

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