...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Mouse Odf2 localizes to centrosomes and basal bodies in adult tissues and to the photoreceptor primary cilium
【24h】

Mouse Odf2 localizes to centrosomes and basal bodies in adult tissues and to the photoreceptor primary cilium

机译：小鼠Odf2定位于成人组织中的中心体和基体以及光感受器初级纤毛

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Odf2 (outer dense fiber 2) is the major protein of the cytoskeleton of the sperm tail. In somatic cells, it is a component of the centrosome in which it is located in the appendages of the mother centriole. Additionally, as shown previously by forced expression in cultured cells, Odf2 localizes to centrioles, basal bodies, and primary cilia, which are all structurally and functionally interconnected. The importance of Odf2 has become obvious by the absence of primary cilia in Odf2-deficient cells and by the embryonic lethality of the Odf2 gene trap insertional mouse. However, nothing is known about the endogenous localization of Odf2 in the tissues of adult mice. We show here that Odf2 protein localizes to centrosomes, to photoreceptor primary cilia, and to basal bodies of ciliated cells of the respiratory epithelium and of the kidney. Our results thus suggest that Odf2 contributes to assorted ciliopathies.
机译：Odf2（外部密集纤维2）是精子尾巴细胞骨架的主要蛋白质。在体细胞中，它是中心体的一个组成部分，位于母体中心粒的附肢中。此外，如先前在培养细胞中的强制表达所示，Odf2定位于中心粒，基体和初级纤毛，它们在结构和功能上都相互关联。在缺乏Odf2的细胞中不存在初级纤毛以及通过Odf2基因陷阱插入小鼠的胚胎致死性，Odf2的重要性已变得显而易见。但是，关于成年小鼠组织中Odf2的内源性定位一无所知。我们在这里显示Odf2蛋白定位于中心体，光感受器原发纤毛以及呼吸道上皮和肾脏的纤毛细胞的基体。因此，我们的结果表明Odf2有助于各种纤毛病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号