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A case report of the anti-glomerular basement membrane glomerulonephritis with mesangial IgA deposition

机译：抗肾小球基底膜肾小球肾炎伴肾小球膜IgA沉积的一例报告

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摘要

A 46-year-old Japanese male with a past medical history of microscopic hematuria presented with nausea, vomiting, and abdominal pain for which he had been diagnosed with rapidly progressive glomerulonephritis with a peak serum creatinine of 6.6 mg/dL and anti-glomerular basement membrane antibody of 214 EU. Light microscopy showed cellular crescent formation, and immunofluorescence illustrated both linear staining of IgG along the glomerular basement membrane and granular staining of IgA and C3 in the mesangial area; however, the PAS staining of mesangial expansions and mesangial proliferations were not observed. Clinical and histological findings suggested anti-glomerular basement membrane glomerulonephritis with mesangial IgA deposition, suggesting IgA nephropathy, a rare condition.
机译：一名46岁的日本男性，曾有镜下血尿病史，伴有恶心，呕吐和腹痛，已被诊断为快速进行性肾小球肾炎，血清肌酐峰值为6.6mg / dL，抗肾小球基底214EU的膜抗体光学显微镜显示细胞形成新月，免疫荧光显示肾小球基底膜上的IgG线性染色和肾小球系膜区域的IgA和C3颗粒染色。然而，未观察到肾小球膜扩张和肾小球膜增生的PAS染色。临床和组织学发现提示抗肾小球基底膜肾小球肾炎伴肾小球系膜IgA沉积，提示IgA肾病是一种罕见病。

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