• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>CEN Case Reports >Lupus-like glomerulonephritis: an autoimmune complication of hepatitis C infection
【24h】

Lupus-like glomerulonephritis: an autoimmune complication of hepatitis C infection

机译：狼疮样肾小球肾炎：丙型肝炎感染的自身免疫并发症

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lupus-like glomerulnephritis in patients with negative lupus serologies and no extra-renal manifestations of lupus can create a diagnostic dilemma. We describe a 53-year-old gentleman with chronic hepatitis C virus (HCV) infection who presented with dialysis-requiring renal failure, renal histologic findings of “full-house” immunofluorescence label and tubuloreticular inclusions on electronic microscopy, but no extra-renal or laboratory signs of systemic lupus erythematosis. Attempted treatment with cyclophosphamide and corticosteroids was limited by cyclophosphamide hypersensitivity. The patient remained dialysis-dependent over 18 months of observation and did not develop extra-renal clinical or biological manifestations of lupus. Mimics of seronegative lupus with isolated renal involvement can include HCV-related autoimmunity. Treatment of acute glomerulonephritis may be similar initially, but other concerns in patients with HCV infection include excluding cryoglobulinemia, the potential impact of immunosuppression therapy on liver disease and consideration of subsequent use of antiviral therapy. Given the increasing prevalence of HCV globally, the recognition of extra-hepatic autoimmune manifestations of HCV infection will likely increase.
机译：狼疮血清学阴性且没有狼疮的肾外表现的患者患有狼疮样肾小球肾炎会造成诊断上的两难境地。我们描述了一位患有慢性丙型肝炎病毒（HCV）感染的53岁绅士，他表现出需要透析的肾衰竭，“全房”免疫荧光标记的肾脏组织学发现和电子显微镜下的肾小管包涵体，但没有肾外或系统性红斑狼疮的实验室体征。环磷酰胺超敏性限制了尝试用环磷酰胺和皮质类固醇治疗。在18个月的观察中，患者仍然依赖于透析，并且未出现狼疮的肾外临床或生物学表现。伴有孤立肾脏累及的血清阴性狼疮的模仿物可包括HCV相关的自身免疫。急性肾小球肾炎的治疗最初可能相似，但HCV感染患者的其他担忧包括排除冷球蛋白血症，免疫抑制疗法对肝病的潜在影响以及考虑随后使用抗病毒疗法。鉴于全球HCV的患病率不断上升，对HCV感染的肝外自身免疫表现的认识可能会增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号