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首页> 外文期刊>CEN Case Reports >Granulomatous interstitial nephritis in a renal allograft
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Granulomatous interstitial nephritis in a renal allograft

机译：肾同种异体肉芽肿性间质性肾炎

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We describe a middle-aged woman in whom granulomatous interstitial nephritis (GIN) developed in a renal allograft. She had undergone bowel resection due to an uncertain diagnosis of active granulomatous bowel disease 30 years earlier. Thereafter, frequent hyperoxaluria as well as calcium oxalate stone and recurrent urinary tract infections had resulted in a progressive deterioration in kidney function over a period of 20 years. She underwent living donor kidney transplantation; however, her kidney function progressively deteriorated, despite transplantation. A biopsy of the renal allograft revealed GIN with granulomatous vasculitis accompanied by calcium oxalate crystals. These as well as the laboratory findings indicated a diagnosis of sarcoidosis. We considered that the aggravated granulomatous inflammation on the allograft was caused by recurrent sarcoidosis accompanied by hyperoxaluria.
机译：我们描述了一个中年妇女，其中在肾同种异体移植中出现肉芽肿性间质性肾炎（GIN）。由于30年前患有活动性肉芽肿性肠病的不确定诊断，她接受了肠切除术。此后，频繁的高草酸尿症以及草酸钙结石和尿路反复感染已导致20年来肾脏功能逐渐恶化。她接受了活体供体肾移植。然而，尽管进行了移植，但她的肾脏功能却逐渐恶化。肾同种异体移植活检显示，GIN伴肉芽肿性血管炎并伴有草酸钙晶体。这些以及实验室检查结果均提示结节病。我们认为同种异体移植物上肉芽肿性炎症的加剧是由结节病伴发高草酸尿引起的。

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