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首页> 外文会议>Conference of the American^College^of^Veterinary^Internal^Medicine >ASSESSMENT OF REPEATED ADMINISTRATION OF A FELINE FVRCP VACCINE AS A MODEL FOR INTERSTITIAL NEPHRITIS
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ASSESSMENT OF REPEATED ADMINISTRATION OF A FELINE FVRCP VACCINE AS A MODEL FOR INTERSTITIAL NEPHRITIS

机译：评估猫素FVRCP疫苗的重复施用作为间质肾炎的模型

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Progressive interstitial nephritis (IN) is the primary cause of feline chronic kidney disease which is considered to be the leading cause of death in adult cats. The Crandell Rees feline kidney (CRFK) cell line is commonly used to grow feline herpesvirus 1 (FHV-1), cahcivirus, and panleukopenia virus used in (FVRCP) vaccine production. Previous studies have shown that cats administered FVRCP vaccines parenterally develop antibodies against CRFK lysates and alpha enolase (glycolytic pathway enzyme inall mammalian cells) and these antibodies can bind to feline renal cell lysates. In addition, three of six cats that were hyperinoculated (11 injections) with CRFK lysates over two years had IN on renal biopsy collected two weeks after the last booster.The primary objective of this study was to determine whether IN could be induced over 16 weeks by repeatedly administering a market leading parenteral FVRCP vaccine to potentially use as a short term model to study biomarkers associated with IN in cats.
机译：渐进间质性肾炎（IN）是一种被认为是死亡的成年猫的首要原因猫慢性肾脏病的主要原因。该克兰德尔里斯猫肾（CRFK）细胞系是常用的成长猫疱疹病毒1（FHV-1），在（FVRCP）疫苗生产用cahcivirus，和猫瘟病毒。先前的研究已经表明，猫给药FVRCP疫苗肠胃外研制抗CRFK裂解物和α-烯醇化酶（糖酵解途径酶inall哺乳动物细胞）抗体和这些抗体可以结合于猫肾细胞裂解物。此外，三个被hyperinoculated是六只猫（11次注射）与CRFK裂解液在两年内曾在肾活检收集的最后booster.The主要目的这项研究的后两周是确定是否可以在16周内诱导通过反复给予市场领先的肠道FVRCP疫苗作为一种短期模型与猫相关的生物标志物研究潜在使用。

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