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首页> 外文期刊>Chemical Research in Chinese Universities >Isolation and Structure Elucidation of an Antifungal Antibiotics A73 Produced By a Soil Fungus Strain No. 131
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Isolation and Structure Elucidation of an Antifungal Antibiotics A73 Produced By a Soil Fungus Strain No. 131

机译:131号土壤真菌菌株产生的抗真菌抗生素A73的分离和结构鉴定

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摘要

Morphological deformation of mycelia or conidia of microorganisms, such as curling, Swelling, hyper-divergency, bead formation, and so on, along with inhibition of germina- Tion, is often induced in the presence of bioactive substance~[1,2]. A bioassay detection defor- Mation or inhibition of mycelia germinated from conidia of P. oryzae P-2b has been modified For quantitative application. This bioassay method could be efficiently applied to the prima- Ry screening of antineoplastic and antifungal agents such as griseofulvin, rhizoxin, Fusarielin A~[5] from the metabolites of fungi.
机译:在存在生物活性物质的情况下,通常会诱发微生物的菌丝体或分生孢子的形态变形,例如卷曲,肿胀,过度发散,形成小珠等,以及对细菌的抑制作用[1,2]。生物测定检测法改变或抑制了米曲霉P-2b分生孢子萌发的菌丝体,可用于定量应用。该生物测定方法可有效地用于从真菌代谢物中筛选抗肿瘤药和抗真菌药,如灰黄霉素,根瘤菌素,富沙瑞林A〜[5]。

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