Templates That Induce α-Helical, β-Sheet, and Loop Conformations

Joel P. Schneider; Jeffery W. Kelly

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Templates That Induce α-Helical, β-Sheet, and Loop Conformations

机译：产生α-螺旋，β-Sheet和环构象的模板

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Polypeptides composed of 30 amino acid residues or less typically do not adopt well-defined conformations in aqueous solution; rather they adopt an ensemble of energetically similar conformations. The small free energy difference (3-15 kcal/mol) that stabilizes the folded state of a native protein over the unfolded state is difficult to achieve in a small polypeptide as the difference in free energy between the folded and unfolded state is derived from the difference between two large numbers representing entropic and enthalpic contributions from both the solvent and the polypeptide chain.

机译：由30个或更少氨基酸残基组成的多肽通常在水溶液中不具有明确定义的构象；相反，他们采用了在能量上类似的整体结构。在小的多肽中很难实现稳定天然蛋白质在未折叠状态的折叠状态的小自由能差（3-15 kcal / mol），因为折叠和未折叠状态之间的自由能差源自于代表溶剂和多肽链的熵和焓贡献的两个大数之差。

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来源
《Chemical Reviews》 |1995年第6期|p.2169-2187|共19页
作者
Joel P. Schneider; Jeffery W. Kelly;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类化学;化学工业;
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1. TUBULAR ARCHITECTURES FROM POLYMERS WITH TAPERED SIDE GROUPS - ASSEMBLY OF SIDE GROUPS VIA A RIGID HELICAL CHAIN CONFORMATION AND FLEXIBLE HELICAL CHAIN CONFORMATION INDUCED VIA ASSEMBLY OF SIDE GROUPS [J] . Percec V., Ronda JC., Johansson G., Macromolecules . 1996,第5期

机译：带有侧锥组的聚合物的管状结构-通过刚性侧链和通过侧组的组装产生的柔性螺旋链构型来组装侧基
2. BETA-LOOP, GAMMA-LOOP, AND HELICAL PEPTIDE CONFORMATIONS IN CYCLOPEPTIDES CONTAINING A STEROIDAL PSEUDO-AMINO ACID [J] . Albert D., Feigel M. Helvetica chimica acta . 1997,第7期

机译：β-环，γ-环和螺旋肽构型在甾体类伪氨基酸中的环肽中
3. PROTEIN-LOOP MIMETICS - A DIKETOPIPERAZINE-BASED TEMPLATE TO STABILIZE LOOP CONFORMATIONS IN CYCLIC PEPTIDES CONTAINING THE NPNA AND RGD MOTIFS [J] . Bisang C., Robinson JA., Weber C. Helvetica chimica acta . 1996,第7期

机译：蛋白质环模拟物-基于二酮哌嗪的模板，可稳定包含NPNA和RGD分子的环肽中的环构象
4. Stimuli-induced Conformational Control of Helical Conjugated Poly(isocyanide)s derived from Amino Acids. [C] . Yuki I. Yamada, Tomokazu Iyoda Meeting,Division of Polymeric Material: Science and Engineering American Chemical Society . 2004

机译：衍生自氨基酸的刺激诱导的螺旋缀合聚（异氰化物）S的构象控制。
5. Ligand-induced conformations of extracellular loop 2 of AT1R . [D] . Unal, Hamiyet. 2010

机译：配体诱导的AT1R细胞外环2的构象。
6. Double-stranded DNA templates can induce alpha-helical conformation in peptides containing lysine and alanine: functional implications for leucine zipper and helix-loop-helix transcription factors. [O] . N P Johnson, J Lindstrom, W A Baase, 1994

机译：双链DNA模板可以在包含赖氨酸和丙氨酸的肽中诱导α-螺旋构象：亮氨酸拉链和螺旋-环-螺旋转录因子的功能含义。
7. Double-stranded DNA templates can induce alpha-helical conformation in peptides containing lysine and alanine: functional implications for leucine zipper and helix-loop-helix transcription factors. [O] . Johnson, N P, Lindstrom, J, Baase, W A, 1994

机译：双链DNA模板可以在包含赖氨酸和丙氨酸的肽中诱导α-螺旋构象：亮氨酸拉链和螺旋-环-螺旋转录因子的功能含义。

Templates That Induce α-Helical, β-Sheet, and Loop Conformations

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