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Human Salt Taste and the Lingual Surface Potential Correlate

机译：人盐味与舌表面电位相关

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摘要

We have demonstrated in humans that Na+ evokes changes in the lingual surface potential (LSP) using a custom chamber. To assess whether a relationship exists between the Na+-evoked changes in the LSP and the intensity of salt taste, we measured the LSP and the intensity of salt taste simultaneously in 7 subjects using test solutions (50, 100, 300, and 1000 mM NaCl) presented in random order. The evoked LSPs and intensity scores correlated with one another well (r2 = 0.992, P 0.01). We then screened 14 subjects for their ability to discriminate between 100 and 300 mM NaCl using the chamber. Three subjects were consistently capable of distinguishing the salt concentrations. In these 3 subjects, an inhibitor of the epithelial sodium channel, amiloride (10 μM), blocked the ability to distinguish salt concentrations and affected the LSP. These data suggest that the LSP may be a component of the signal transduction system involved in human salt taste. In adept salt tasters, an amiloride-sensitive mechanism appears to have a role in distinguishing salt concentrations.
机译：我们已经在人类中证明，Na + 会使用自定义腔室引起舌表面电位（LSP）的变化。为了评估LSP中Na + 引起的变化与盐味强度之间是否存在关系，我们使用测试溶液同时测量了7名受试者的LSP和盐味强度（50， 100、300和1000 mM NaCl）以随机顺序显示。诱发的LSPs和强度得分彼此相关（r 2 = 0.992，P <0.01）。然后，我们使用反应室筛选了14位受试者区分100至300 mM NaCl的能力。三名受试者始终能够区分盐浓度。在这3位受试者中，上皮钠通道抑制剂阿米洛利（10μM）阻断了区分盐浓度的能力并影响了LSP。这些数据表明，LSP可能是人类盐味所涉及的信号转导系统的组成部分。在熟练的盐品尝师中，阿米洛利敏感机制似乎在区分盐浓度中起作用。

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    《Chemical Senses》 |2009年第5期|p.373-382|共10页
  • 作者

    George M. Feldman123 Gerard L. Heck2 and Nancy L. Smith4;

  • 作者单位

    1Department of Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA 2Department of Physiology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA 3Medical Service, Hunter Holmes McGuire Veterans Affairs Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA 4Research Service, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, VA 23249, USA;

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