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首页> 外文期刊>Chimia >Platinum Pyrimidine Blues: Still a Challenge to Bioinorganic Chemists and a Treasure for Coordination Chemists
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Platinum Pyrimidine Blues: Still a Challenge to Bioinorganic Chemists and a Treasure for Coordination Chemists

机译：铂嘧啶蓝调：仍然是对生物无机化学家的挑战，也是配位化学家的宝藏

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摘要

A class of intensely colored platinum complexes, derived from the hydrolysis product of the antitumor agent cisplatin, cis-[Pt(NH_3)_2(H_2O)_2]~(2+), and pyrimidine nucleobases (pym) and related cyclic or open amides, and generally termed 'Platinum Blues', is discussed. First reported over 30 years ago, major questions concerning their nature have been solved since then, for example their mixed valency and paramagnetism. Their modes of action as antitumor agents and as nucleic acid stains remain elusive, however. It has generally been assumed that the 'Blues' adopt linear chain structures, thus permitting short Pt···Pt contacts, but more recent findings demonstrate that these ligands also allow cyclic structures to be formed (metallacalix[n]arenes). They provide a wealth of interesting properties with regard to host-guest chemistry and non-covalent DNA binding. These developments are reviewed.
机译：一类强烈着色的铂络合物，由抗肿瘤药顺铂，顺式[[Pt（NH_3）_2（H_2O）_2]〜（2+）和嘧啶核碱基（pym）以及相关的环状或开放式酰胺的水解产物衍生而来，并且通常称为“白金蓝调”。自30年前首次报道以来，有关其性质的主要问题从那时起就得到了解决，例如它们的化合价和顺磁性。然而，它们作为抗肿瘤剂和核酸染色剂的作用方式仍然难以捉摸。通常认为，“蓝调”采用线性链结构，因此允许短的Pt···Pt接触，但是最近的发现表明这些配体也允许形成环状结构（metallacalix [n]芳烃）。它们提供了关于来宾-客体化学和非共价DNA结合的许多有趣特性。这些发展进行了审查。

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