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Targeted nanoparticle binding & detection in petroleum hydrocarbon impacted porous media

机译：石油烃影响的多孔介质中的靶向纳米颗粒结合和检测

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Targeted nanoparticle binding has become a core feature of experimental pharmaceutical product design which enables more efficient payload delivery and enhances medical imaging by accumulating nanoparticles in specific tissues. Environmental remediation and geophysical monitoring encounter similar challenges which may be addressed in part by the adoption of targeted nanoparticle binding strategies. This study illustrates that engineered nanoparticles can bind to crude oil-impacted silica sand, a selective adsorption driven by active targeting based on an amphiphilic polymer coating. This coating strategy resulted in 2 mg/kg attachment to clean silica sand compared to 8 mg/kg attachment to oil-impacted silica sand. It was also shown that modifying the surface coating influenced the binding behaviour of the engineered nanoparticles - more hydrophobic polymers resulted in increased binding. Successful targeting of Pluronic-coated iron oxide nanoparticles to a crude oil and silica sand mixture was demonstrated through a combined quantitative Orbital Emission Spectroscopy mass analysis supported by Vibrating Scanning Magnetometer magnetometry, and a qualitative X-ray micro-computed tomography (CT) visualization approach. These non-destructive characterization techniques facilitated efficient analysis of nanoparticles in porous medium samples with minimal sample preparation, and in the case of X-Ray CT, illustrated how targeted nanoparticle binding may be used to produce 3-D images of contaminated porous media. This work demonstrated successful implementation of nanoparticle targeted binding toward viscous LNAPL such as crude oil in the presence of a porous medium, a step which opens the door to successful application of targeted delivery technology in environmental remediation and monitoring. (C) 2018 Published by Elsevier Ltd.
机译：靶向纳米颗粒结合已成为实验药物产品设计的核心特征，该设计能够通过在特定组织中积累纳米颗粒，实现更有效的有效载荷传输并增强医学成像。环境修复和地球物理监测也遇到了类似的挑战，可以通过采用有针对性的纳米粒子结合策略来部分解决。这项研究表明，经过工程改造的纳米颗粒可以与受原油影响的硅砂结合，这是基于两亲聚合物涂层的主动靶向驱动的选择性吸附。这种涂层策略导致清洁的硅砂附着量为2 mg / kg，而油浸的硅砂附着量为8 mg / kg。还显示出改性表面涂层会影响工程化纳米颗粒的结合行为-疏水性更高的聚合物会导致结合增加。通过振动扫描磁强计磁力分析和定性X射线微计算机断层扫描（CT）可视化方法的组合定量轨道发射光谱质量分析，证明了将Pluronic涂层的氧化铁纳米颗粒成功靶向原油和硅砂混合物。这些无损表征技术有助于以最少的样品制备效率对多孔介质样品中的纳米颗粒进行有效分析，在X射线CT的情况下，说明了靶向纳米颗粒结合可如何用于产生受污染的多孔介质的3-D图像。这项工作证明了在多孔介质的存在下成功地实现了与粘性LNAPL（例如原油）的纳米颗粒靶向结合，这一步骤为靶向递送技术在环境修复和监测中的成功应用打开了大门。 （C）2018由Elsevier Ltd.发布

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