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首页> 外文期刊>Chemosphere >Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers
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Evaluation of gas chromatography-atmospheric pressure chemical ionization tandem mass spectrometry as an alternative to gas chromatography tandem mass spectrometry for the determination of polychlorinated biphenyls and polybrominated diphenyl ethers

机译：气相色谱-常压化学电离串联质谱法替代气相色谱串联质谱法测定多氯联苯和多溴联苯醚的评估

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摘要

A method for the analysis of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in serum was developed using gas chromatography coupled to tandem mass spectrometry with atmospheric pressure chemical ionization (GC-APCI-MS/MS). The ionization and fragmentation performance of APCI were evaluated and compared with those of electron ionization (EI). In contrast to extensive fragmentation caused by El with high energy, soft ionization achieved by APCI produced mass spectra dominated by molecular ions from the first stage of MS analysis. Better sensitivity and selectivity achieved by the GC-APCI-MS/MS method allowed to analyze serum samples with a low volume (100 mu L). The limits of detection (LODs) ranged from 0.067 to 14 pg/mL for the analysis in serum samples. The developed method was evaluated at three spiking levels (0.05, 0.5 and 5 ng/mL for PCBs), showing good recoveries and repeatability. The recoveries ranged from 74.0% to 130.5%, and the relative standard deviations (RSDs) were less than 20%, for all analytes. The determination of PCBs and PBDEs in the human serum samples by GC-APCI-MS/MS was compared with gas chromatography -tandem mass spectrometry with El (GC-EI-MS/MS). BDE-99 and BDE-100 were successfully quantified by GC-APCI-MS/MS, while these two PBDE congeners were not detected by GC-EI-MS/MS. The GC-APCI-MS/MS method had a clear advantage when analyzing compounds at low levels. (C) 2019 Elsevier Ltd. All rights reserved.
机译：利用气相色谱-串联质谱联用大气压化学电离（GC-APCI-MS / MS），开发了一种分析血清中多氯联苯（PCB）和多溴联苯醚（PBDE）的方法。评估了APCI的电离和碎片化性能，并将其与电子电离（EI）进行比较。与高能态El引起的大范围碎片化相反，APCI实现的软化电离产生的质谱图主要来自MS分析第一阶段的分子离子。通过GC-APCI-MS / MS方法获得的更好的灵敏度和选择性允许分析少量（100μL）的血清样品。血清样品分析的检测限（LOD）为0.067至14 pg / mL。在三种加标水平（PCB的0.05、0.5和5 ng / mL）下对开发的方法进行了评估，显示了良好的回收率和可重复性。所有分析物的回收率在74.0％至130.5％之间，相对标准偏差（RSD）小于20％。将GC-APCI-MS / MS测定人血清样品中的PCBs和PBDEs与El气相色谱-串联质谱法（GC-EI-MS / MS）进行了比较。 BDE-99和BDE-100已通过GC-APCI-MS / MS成功定量，而GC-EI-MS / MS未检测到这两个PBDE同系物。分析低含量化合物时，GC-APCI-MS / MS方法具有明显的优势。 （C）2019 Elsevier Ltd.保留所有权利。

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  • 来源
    《Chemosphere》 |2019年第6期|288-294|共7页
  • 作者

    Fang Jing; Zhao Hongzhi; Zhang Yanhao; Wong Minghung; He Yu; Sun Qianqian; Xu Shunqing; Cai Zongwei;

  • 作者单位

    Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China;

    Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China;

    Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China;

    Southern Univ Sci & Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Soil & Groundwater Pollut, Shenzhen, Peoples R China|Educ Univ Hong Kong, CHEER, Hong Kong, Peoples R China;

    Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China|Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Fujian, Peoples R China;

    Fuzhou Univ, Coll Chem, MOE Key Lab Analyt Sci Food Safety & Biol, Fuzhou 350116, Fujian, Peoples R China;

    Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China|Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Environm Protect, Wuhan, Hubei, Peoples R China|Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm Hlth Incubat, Wuhan, Hubei, Peoples R China;

    Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    APCI; PCBs; PBDEs; Human serum;

    机译：APCI;PCBs;PBDEs;人血清;

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