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首页> 外文期刊>Chemosphere >Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan
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Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan

机译：从日本札幌市的60名母亲那里收集的血液和母乳中的多氯二苯并对二恶英，多氯二苯并呋喃和二恶英样多氯联苯的浓度

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摘要

We measured the concentrations of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), non-ortho polychlorinated biphenyls (non-ortho PCBs), and mono-ortho polychlorinated biphenyls (mono-ortho PCBs) in paired samples of blood and breast milk collected from 60 mothers in Sapporo City, Hokkaido Prefecture, Japan. The present study is one of the few studies in which PCDDs, PCDFs, and dioxin-like PCBs have been measured in blood and breast milk collected from 60 same mothers. Of these 60 mothers, 30 were primipara (mean: 30.1 years, median: 28.0 years) and 30 were multipara (mean: 32.2 years, median: 32.5 years). The arithmetic mean TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in blood and breast milk of the primiparous mothers were 9.0,3.3, 5.7, and 0.4 pg TEQg~(-1) lipid, respectively, and 5.2, 2.2,4.5, and 0.4 pg TEQg~(-1) lipid, respectively, with the total TEQ concentrations of these dioxin-like compounds being 9.3-42.9 (mean: 18.4, median: 17.3) and 7.0-41.1 (mean: 12.3, median: 11.4) pg TEQg~(-1) lipid, respectively. In the case of multiparous mothers, the arithmetic mean TEQ concentrations of these dioxin-like compounds in blood and breast milk were 7.1, 2.7, 5.3, and 0.4 pg TEQg~(-1) lipid, respectively, and 3.9, 1.7, 3.8, and 0.4 pg TEQg~(-1) lipid, respectively, with the total TEQ concentrations being 3.4-28.1 (mean: 15.5, median: 13.9) and 2.7-20.0 (mean: 9.8, median: 9.2) pg TEQg~(-1) lipid, respectively. The total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in blood and breast milk of primiparous mothers in Sapporo City appeared to be generally lower than those recently surveyed throughout the greater area of Japan. Significant correlations were observed between age and the total TEQ concentrations of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in the blood of primiparae and multiparae, and significant correlations were also observed between age and the total TEQ concentrations of these dioxin-like compounds in the breast milk of primiparae and multiparae. The total TEQ concentrations of PCDDs, PCDFs, and dioxin-like PCBs in the blood of primiparous mothers showed a close correlation to those in their breast milk and also showed good correlations between the total TEQ concentrations of these dioxin-like compounds in the blood of multiparous mothers and those in their breast milk. The result of a comparison of the arithmetic mean concentrations of each congener of PCDDs, PCDFs, non-ortho PCBs, and mono-ortho PCBs in blood and breast milk indicated that the transfer of octachlorodibenzo-p-dioxin (OCDD) from the blood to the breast milk was lower than those of other congeners. In contrast, among mono-ortho PCBs congeners, the arithmetic mean concentrations of 2,3',4,4',5-pentachlorobiphenyl (PentaCB) (#118) and 2,3,3',4,4'-PentaCB (#105) in the breast milk were slightly higher than those in the blood, which suggested that breast-fed infants may be at higher risk from mono-ortho PCBs.
机译：我们测量了成对血液样本中多氯二苯并对二恶英（PCDDs），多氯二苯并呋喃（PCDFs），非邻多氯联苯（non-ortho PCBs）和单邻多氯联苯（mono-ortho PCBs）的浓度以及从日本北海道札幌市的60名母亲那里收集的母乳。本研究是从60位相同母亲那里采集的血液和母乳中检测出PCDDs，PCDFs和二恶英样PCB的少数研究之一。在这60名母亲中，有30名是初产妇（平均：30.1岁，中位数：28.0岁），还有30名是多产妇（平均：32.2岁，中位数：32.5岁）。初产母亲的血液和母乳中PCDDs，PCDFs，非原位PCB和单原位PCB的算术平均TEQ浓度分别为9.0、3.3、5.7和0.4 pg TEQg〜（-1）脂质，并且TEQg〜（-1）脂质分别为5.2、2.2、4.5和0.4 pg，这些二恶英样化合物的总TEQ浓度为9.3-42.9（平均值：18.4，中位数：17.3）和7.0-41.1（平均值： 12.3，中位数：11.4）pg TEQg〜（-1）脂质。在多胎母亲的情况下，血液和母乳中这些二恶英样化合物的算术平均TEQ浓度分别为7.1、2.7、5.3和0.4 pg TEQg〜（-1）脂质，以及3.9、1.7、3.8， TEQg〜（-1）和0.4 pg TEQg〜（-1）脂质，总TEQ浓度分别为3.4-28.1（平均值：15.5，中位数：13.9）和2.7-20.0（平均值：9.8，中位数：9.2）pg TEQg〜（-1 ）脂质。札幌市初产母亲的血液和母乳中PCDDs，PCDFs，非原位多氯联苯和单原位多氯联苯的总TEQ浓度似乎总体上低于最近在日本整个大区进行的调查。观察到年龄与初乳和多乳血液中PCDDs，PCDFs，非邻位多氯联苯和单邻位多氯联苯的年龄与总TEQ浓度之间存在显着相关性，并且还观察到年龄与这些二恶英的总TEQ浓度之间存在显着相关性初乳和多乳母乳中的类似化合物。初产母亲血液中PCDDs，PCDFs和二恶英样多氯联苯的总TEQ浓度与母乳中的总TEQ浓度密切相关，并且这些二恶英样化合物在血液中的总TEQ浓度之间也显示出良好的相关性。多产的母亲以及那些母乳中的母亲。比较血液和母乳中PCDDs，PCDFs，非邻位多氯联苯和单邻位多氯联苯各同系物的算术平均浓度，结果表明八氯二苯并-对-二恶英（OCDD）从血液转移至母乳低于其他同类婴儿。相比之下，在单正交多氯联苯同类物中，2,3'，4,4'，5-五氯联苯（PentaCB）（＃118）和2,3,3'，4,4'-PentaCB（ ＃105）的母乳中的血液含量略高于血液中的母乳，这表明母乳喂养的婴儿患单原位多氯联苯的风险可能更高。

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