...
首页> 外文期刊>Child Neuropsychology >Executive and Attention Functioning Among Children in the PANDAS Subgroup
【24h】

Executive and Attention Functioning Among Children in the PANDAS Subgroup

机译:PANDAS小组儿童的执行力和注意力功能

获取原文
获取原文并翻译 | 示例
           

摘要

Evidence from past studies indicates that adults and children with Obsessive-Compulsive Disorder (OCD) and Tourette syndrome (TS) experience subtle neuropsychological deficits. Less is known about neuropsychological functioning of children and adolescents with a symptom course consistent with the PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection) subgroup of OCD and tics. To provide such information, we administered three tests of attention control and two of executive function to 67 children and adolescents (ages 5-16) diagnosed with OCD and/or tics and a symptom course consistent with the PANDAS subgroup and 98 healthy volunteers (HV) matched by age, sex, and IQ. In a paired comparison of the two groups, the PANDAS subjects were less accurate than HV in a test of response suppression. Further, in a two-step linear regression analysis of the PANDAS group in which clinical variables were added stepwise into the model and in the second step matching variables (age, sex, and IQ) were added, IQ emerged as a predictor of performance on this task. In the same analysis, ADHD diagnosis and age emerged as predictors of response time in a continuous performance task. Subdividing the PANDAS group by primary psychiatric diagnosis revealed that subjects with TS or OCD with tics exhibited a longer response time compared to controls than subjects with OCD only, replicating previous findings within TS and OCD. This study demonstrates that children with PANDAS exhibit neuropsychological profiles similar to those of their primary psychiatric diagnosis.
机译:以往研究的证据表明,患有强迫症(OCD)和图雷特综合征(TS)的成人和儿童会出现细微的神经心理学缺陷。关于儿童和青少年的神经心理学功能,其症状过程与强迫症和抽搐的PANDAS(与链球菌感染有关的小儿自身免疫性神经精神障碍)亚组一致,人们对此知之甚少。为了提供此类信息,我们对67名被诊断患有OCD和/或抽动的儿童和青少年(5-16岁)和与PANDAS亚组一致的症状过程和98名健康志愿者(HV)进行了三项注意力控制测试和两项执行功能测试)匹配的年龄,性别和智商。在两组的配对比较中,在响应抑制测试中,PANDAS受试者的准确性不如HV。此外,在PANDAS组的两步线性回归分析中,将临床变量逐步添加到模型中,并在第二步中添加了匹配变量(年龄,性别和智商),智商逐渐成为表现的预测指标。这个任务。在同一分析中,ADHD诊断和年龄已成为连续执行任务中反应时间的预测指标。将PANDAS组按主要精神病学诊断进行细分后发现,与仅具有OCD的受试者相比,具有抽动的TS或OCD受试者与对照组相比显示出更长的响应时间,复制了TS和OCD内的先前发现。这项研究表明,患有PANDAS的儿童表现出的神经心理学特征与他们最初的精神病诊断相似。

著录项

  • 来源
    《Child Neuropsychology》 |2009年第2期|179-194|共16页
  • 作者单位

    Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA|Johns Hopkins University, Baltimore, Maryland, USA;

    Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA|University of Florida College of Medicine, Gainesville, Florida, USA;

    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA;

    Weill Medical College of Cornell University, Sackler Institute for Developmental Psychobiology, New York, New York, USA|Department of Psychology, Columbia University, Social Cognitive Affective Neuroscience Unit, New York, New York, USA;

    Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA;

    Weill Medical College of Cornell University, Sackler Institute for Developmental Psychobiology, New York, New York, USA;

    Department of Health and Human Services, Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    PANDAS; Executive functioning; Attention; Obsessive-compulsive disorder; Tourette syndrome;

    机译:潘达斯执行职能;注意;强迫症;抽动秽语综合征;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号