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Neuropsychological Profile of Children with Cryptogenic Localization Related Epilepsy

机译：隐源性定位癫痫患儿的神经心理学档案

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Up to one third of the epilepsy population consists of children with cryptogenic localization related epilepsy (CLRE). Unfortunately, the effect of CLRE on the development is still unclear. Behavioral and academic problems have been reported, but no conclusive study concerning the impact of CLRE on neuropsychological functioning is yet published. This study was a systematic cross-sectional open clinical and nonrandomized investigation, which included 68 children with CLRE. Several neuropsychological tests were analyzed and age-related normative values were used as reference. Differences between CLRE and reference values were tested with Paired-Samples t-tests. Z scores were computed to compare the different neuropsychological tests and to inspect whether a characteristic neuropsychological profile exists for CLRE. The Independent-Samples t-test was used to explore which epilepsy factors (seizure type, seizure frequency, age at onset, duration of epilepsy, and drug load) were influencing the cognitive profile of CLRE. There seems to be a characteristic cognitive profile for children with CLRE; children with CLRE experience cognitive difficulties on a wide range of areas—in particular, alertness, mental speed, and memory. Seizure type, seizure frequency, duration of epilepsy, and drug load do not influence this neuropsychological profile. Age at onset was an important risk factor; the earlier the age at onset, the worse the cognitive performance. In spite of the influence of age at onset, the revealed profile can be seen as a stable, independent of temporary factors, neuropsychological profile for children with CLRE.
机译：多达三分之一的癫痫患者由患有隐源性定位相关性癫痫（CLRE）的儿童组成。不幸的是，CLRE对发育的影响仍然不清楚。已经报道了行为和学术问题，但尚未发表有关CLRE对神经心理学功能影响的结论性研究。这项研究是一项系统的，开放性的临床和非随机性横断面调查，其中包括68名CLRE儿童。分析了几种神经心理学测试，并使用了与年龄有关的规范值作为参考。使用配对样本t检验测试CLRE和参考值之间的差异。计算Z得分以比较不同的神经心理学测验并检查CLRE是否存在特征性神经心理学特征。独立样本t检验用于探讨哪些癫痫病因素（癫痫发作类型，癫痫发作频率，发病年龄，癫痫发作持续时间和药物负荷）影响CLRE的认知状况。患有CLRE的儿童似乎具有特征性的认知特征。患有CLRE的儿童在很多领域都会遇到认知困难，特别是机敏性，心理速度和记忆力。癫痫发作类型，癫痫发作频率，癫痫发作的持续时间和药物负荷不会影响这种神经心理学特征。发病年龄是重要的危险因素。发病年龄越早，认知能力越差。尽管发病年龄受到影响，但CLRE患儿所揭示的特征可被视为稳定的，独立于临时因素的神经心理学特征。

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