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首页> 外文期刊>The Chinese-German Journal of Clinical Oncology >Percutaneous Radiofrequency Ablation for Hepatic Malignancies
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Percutaneous Radiofrequency Ablation for Hepatic Malignancies

机译：经皮射频消融治疗肝恶性肿瘤

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Objective To study the therapeutic efficay of percutaneous radiofrequency ablation (PRFA) for hepatic malignancies and to define its indications and its criteria of the curative effect. Methods In 100 patients with histologicallly or clinically confirmed hepatocellular carcinoma (HCC) or liver metastases we performed PRFA under ultrasound guidance using LeVeen multipolar array needle electrode and RF 2000 generator. All patients were followed to identify complications and to assess treatment response. Results PRFA was performed in 76 patients with HCC and in 24 with liver metastases. The Alpha-fetoprotein (AFP) levels of the AFP positive HCC patients with inoperable small HCCs decreased to normal in 75.0% (21/28) and decreased markedly in 21.4% (6/28). Complete necrosis of small hepatic malignancies, documented by magnetic resonance imaging (MRI) was a-chieved in 85.9% (61/71). If the tumor shows iso- or hyper-intensity on T1-weighted images, and relative hypointensity on T2-weighted images, and no enhanced intensity on dynamic contrast-enhanced MR imaging, it is considered completely coagulated. Conclusion PRFA is a novel local thermal palliative therapy for small hepatic malignancies that is minimally invasive, safe and effective. In patients with large lesions it can be combined with transarterial chemoembolization (TACE). Critera for curative treatment are normalization of serum AFP and/or MRI or CT scan findings showing complete necrosis.
机译：目的研究经皮射频消融术（PRFA）治疗肝恶性肿瘤的疗效，并确定其适应症和疗效标准。方法在100例经组织学或临床证实为肝细胞癌（HCC）或肝转移的患者中，我们使用LeVeen多极阵列针电极和RF 2000发生器在超声引导下进行PRFA。跟踪所有患者以发现并发症并评估治疗反应。结果76例HCC患者和24例肝转移患者行PRFA检查。无法操作的小肝癌的AFP阳性HCC患者的甲胎蛋白（AFP）水平降至正常的75.0％（21/28），并显着降低21.4％（6/28）。磁共振成像（MRI）证实小肝恶性肿瘤完全坏死的发生率为85.9％（61/71）。如果肿瘤在T1加权图像上显示等强度或高强度，而在T2加权图像上显示相对低强度，而在动态对比增强MR成像上没有增强的强度，则认为肿瘤已完全凝结。结论PRFA是一种治疗微小肝恶性肿瘤的新型局部热姑息疗法，具有微创，安全，有效的特点。对于具有较大病变的患者，可以将其与经动脉化学栓塞（TACE）结合使用。根治性治疗的标准是血清AFP正常化和/或显示完全坏死的MRI或CT扫描结果。

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