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首页> 外文期刊>Chinese Jouranl of Integrative Medicine >Study of Tripterygium Associated with Nicotinamide in Treating Late-onset Autoimmune Diabetes Mellitus in Adults
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Study of Tripterygium Associated with Nicotinamide in Treating Late-onset Autoimmune Diabetes Mellitus in Adults

机译：雷公藤与烟酰胺联合治疗成人迟发性自身免疫性糖尿病的研究

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Objective: To explore the effect of Tripterygium polyglycoside (TP) associated with nicotin-amide on the islet cell function, immune parameters and lipoperoxide (LPO) in adult patients with late-onset autoimmune diabetes mellitus (LADA). Methods: Thirty-six cases of LADA were randomly divided into three groups: TP group (n = 12), treated with TP plus orally taken metformin; combined treatment group (n = 12), treated with TP combined with nicotinamide and metformin, and control group (n = 12) treated with metformin alone. They were followed-up for 18 months. Results: (1) Compared with the control group after 9 months of treatment, postprandial plasma glucose and LPO in combined treatment group were decreased (P <0.05), and the postprandial C-peptide was higher (P<0.05). At the 18th month, the value of postprandial C-peptide in the TP and combined treatment group was higher than that in the control group. The slL-2R level of both TP and combined treatment groups were lowered (P<0.01); (2) Islet cell antibody (ICA) positive of 5 cases in the TP group and 6 cases in the combined treatment group got converted to the negative respectively, while only one in the control group at the time (P<0.05); (3) The level of LPO in the combined treatment group was significantly lower than that in the TP group at the 18th month of treatment (P<0.05). Conclusion: TP combined with nicotinamide played a role in immunity regulation, decreasing the liter of islet cell antibody and slL-2R, which also reduced the production of LPO and had a tendency to improve islet cell function in early LADA patients.
机译：目的：探讨雷公藤多甙（TP）和烟酰胺对成年迟发性自身免疫性糖尿病（LADA）成人患者胰岛细胞功能，免疫参数和脂过氧化物（LPO）的影响。方法：将36例LADA患者随机分为三组：TP组（n = 12），TP联合口服二甲双胍治疗；联合治疗组（n = 12），TP联合烟酰胺和二甲双胍治疗，对照组（n = 12），单独使用二甲双胍治疗。他们进行了18个月的随访。结果：（1）治疗9个月后，与对照组相比，联合治疗组餐后血浆葡萄糖和LPO降低（P <0.05），餐后C肽升高（P <0.05）。 TP和联合治疗组的餐后C肽值在第18个月时高于对照组。 TP和联合治疗组的slL-2R水平均降低（P <0.01）； （2）TP组5例和联合治疗组6例胰岛细胞抗体（ICA）阳性分别转化为阴性，而对照组当时只有1例（P <0.05）； （3）治疗第18个月，联合治疗组LPO水平显着低于TP组（P <0.05）。结论：TP联合烟酰胺起免疫调节作用，降低了胰岛细胞抗体和slL-2R的含量，降低了LPO的产生，并有改善早期LADA患者胰岛细胞功能的趋势。

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