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首页> 外文期刊>Chinese science bulletin >An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis
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An adpA homologue in Streptomyces avermitilis is involved in regulation of morphogenesis and melanogenesis

机译：阿维链霉菌中的adpA同源物参与形态发生和黑色素形成的调节

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摘要

In Streptomyces griseus, AdpA, the key transcriptional activator in the A-factor regulatory cascade, switches on the transcription of multiple genes required for secondary metabolism and morphological differentiation. Streptomyces avermitilis also contains an ortholog of adpA, which is named adpA-a. To clarify the in vivo function of adpA-a, an adpA-a-disrupted strain was constructed by double crossover recombination. No difference in avermectin production was found between the adpA-a-disruptant and the wild-type strain. However, this disruptant neither formed spores nor produced melanin and its phenotype was restored to the original wild-type by a single copy of the adpA-a gene integrated into the chromosome. This report shows that adpA-a is involved in regulation of morphological differentiation and melanin production in S. avermitilis.
机译：在灰链霉菌中，A因子调节级联反应中的关键转录激活因子AdpA开启了次级代谢和形态分化所需的多个基因的转录。阿维链霉菌还含有adpA的直系同源基因，命名为adpA-a。为了阐明adpA-a的体内功能，通过双交换重组构建了破坏adpA-a的菌株。在adpA-a干扰物和野生型菌株之间没有发现阿维菌素的生产差异。然而，这种破坏剂既不形成孢子也不产生黑色素，并且其表型通过整合到染色体中的单拷贝的adpA-a基因而恢复为原始的野生型。该报告表明，adpA-a参与了阿维链霉菌形态分化和黑色素生成的调控。

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