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Analysis of porcine MHC expression profile

机译：猪MHC表达谱分析

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摘要

The porcine major histocompatibility complex (MHC, also named swine leukocyte antigen, SLA) is associated not only with immune responsibility and disease susceptibility, but also with some reproductive and productive traits such as growth rate and carcass composition. As yet systematical research on SLA expression profile is not reported. In order to illustrate SLA expression comprehensively and deepen our understanding of its function, we outlined the expression profile of SLA in 51 tissues of Landrace by analyzing a large amount of ESTs produced by "Sino-Danish Porcine Genome Project". In addition, we also compared the expression profile of SLA in several tissues from different development stages and from another breed (Erhualian). The result shows: (i) classical SLA genes are highly expressed in immune tissues and middle part of intestine; (ii) although SLA-3 is an SLA Ia gene, its expression abundance and pattern are quite different from those of the other two SLA Ia genes. The same phenomenon is seen in HLA-C expression, suggesting that the two genes may function similarly and undergo convergent evolution; (iii) except in jejunum, the antigen presenting genes are more highly expressed in breed Erhualian than in Landrace. The difference might associate with the higher resistance to bad conditions (including pathogens) of Erhualian and higher growth rates of Land-race.
机译：猪主要组织相容性复合物（MHC，也称为猪白细胞抗原，SLA）不仅与免疫反应和疾病易感性有关，而且与一些生殖和生产性状如生长速率和car体组成有关。迄今为止，尚未报道关于SLA表达谱的系统研究。为了全面地说明SLA的表达并加深我们对其功能的理解，我们通过分析“中丹猪基因组计划”产生的大量EST，概述了SLA在长白的51个组织中的表达概况。此外，我们还比较了SLA在不同发育阶段和另一个品种（Erhualian）的几种组织中的表达谱。结果表明：（i）经典SLA基因在免疫组织和肠中部高表达； （ii）尽管SLA-3是SLA Ia基因，但是其表达丰度和模式与其他两个SLA Ia基因的表达和模式完全不同。在HLA-C表达中可以看到相同的现象，这表明这两个基因可能具有相似的功能并经历趋同进化。 （iii）除了在空肠中，抗原呈递基因在二华联品种中比在地方品种中表达更高。这种差异可能与二花脸对恶劣条件（包括病原体）的较高抵抗力和陆地种族的较高生长率有关。

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