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Analysis of length distribution of short DNA fragments induced by ~7Li ions using the random-breakage model

机译:使用随机断裂模型分析〜7Li离子诱导的短DNA片段的长度分布

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摘要

Deoxyribonucleic acid (DMA) is an important bio-macromolecnle. BNA double strand breaks (BSBs) are considered to be the most important initial damage responsible for all biological effects induced by ionizing radiation. In this paper the length distribution of DNA fragments induced by ~7Li ionizing radiation is fitted with the random breakage model. In this model, the parameter u is the average number of BSBs on every DNA molecule induced by ionizing radiation. The fitting result shows that the random breakage model cannot describe the distribution of DNA fragments in lower doses, while the random breakage model is in better accordance with the experimental data in higher doses. It is shown that the length distribution of DNA fragments has random statistical feature in higher doses. In this situation, the random breakage model looks like a model without any parameter since the " has specific physical meaning and can directly be obtained from experimental data.
机译:脱氧核糖核酸(DMA)是一种重要的生物大分子。 BNA双链断裂(BSB)被认为是最重要的初始损伤,是电离辐射引起的所有生物效应的原因。本文用〜7Li电离辐射诱导的DNA片段长度分布与随机断裂模型拟合。在此模型中,参数u是电离辐射诱导的每个DNA分子上BSB的平均数量。拟合结果表明,随机断裂模型不能描述低剂量DNA片段的分布,而随机断裂模型与较高剂量的实验数据比较吻合。结果表明,高剂量DNA片段的长度分布具有随机统计特征。在这种情况下,随机断裂模型看起来像是没有任何参数的模型,因为“具有特定的物理意义,可以直接从实验数据中获得”。

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