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首页> 外文期刊>Chinese science bulletin >Negative cooperative effect of cytotoxicity of a di-component initiating system for a novel injectable tissue engineering hydrogel
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Negative cooperative effect of cytotoxicity of a di-component initiating system for a novel injectable tissue engineering hydrogel

机译：新型可注射组织工程水凝胶的双组分引发系统的细胞毒性的负协同作用

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摘要

Chemically cross-linked hydrogels constitute a novel injectable tissue engineering material. At present, one of the key problems is to find an appropriate initiator. This study evaluated the cytotoxicity in vitro of a water-soluble redox initiating system consisting of ammonium persulfate (APS) and N, N, N′, N′-tetramethylethylenediamine (TEM-ED). Gelation time of PEG diacrylate macromer in phosphate buffer saline solution was first adjusted to guarantee that the examined initiator concentrations are sufficiently high to trigger polymerization of macromers. NIH/3T3 fi-broblasts were employed to examine cytotoxicity via MTT measurements and optical microscopic observations. It has been found that the combined APS/TEMED system exhibits negative cooperative effect, for the underlying cytotoxicity is even lower than that of APS or TEMED at certain concentrations.
机译：化学交联的水凝胶构成了一种新型的可注射组织工程材料。当前，关键问题之一是找到合适的发起者。这项研究评估了由过硫酸铵（APS）和N，N，N'，N'-四甲基乙二胺（TEM-ED）组成的水溶性氧化还原引发体系的体外细胞毒性。首先调节PEG二丙烯酸酯大分子单体在磷酸盐缓冲盐溶液中的胶凝时间，以确保所检查的引发剂浓度足够高以引发大分子单体的聚合。使用NIH / 3T3成纤维细胞通过MTT测量和光学显微镜观察来检查细胞毒性。已经发现，组合的APS / TEMED系统表现出负的协同作用，因为在某些浓度下潜在的细胞毒性甚至低于APS或TEMED。

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